| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 27 | 27 | 13 | 6 | 2.97 | .252 | 1.01 | 6.3 | 2.8 | 7.5 | 175.2 | 122 | 63 | 58 | 16 | 55 | 146 | 0 | 0 | 0 | 0 | 21 | 1 | 1 | 3.48 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 27 | 27 | 7 | 8 | 3.53 | .300 | 1.25 | 6.5 | 4.7 | 7.5 | 181.0 | 131 | 73 | 71 | 12 | 95 | 151 | 1 | 0 | 0 | 1 | 18 | 7 | 2 | 3.88 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 26 | 26 | 15 | 6 | 3.99 | .296 | 1.24 | 9.1 | 2.1 | 4.8 | 160.0 | 161 | 72 | 71 | 18 | 37 | 85 | 2 | 0 | 0 | 0 | 18 | 4 | 4 | 4.17 |
| SP | Johnson, R.Johnson, Randy † # >> | 41 | 2004 | L | 84 | 27 | 26 | 15 | 4 | 2.96 | .276 | 1.12 | 8.1 | 2.0 | 8.3 | 167.0 | 150 | 56 | 55 | 14 | 37 | 154 | 3 | 0 | 0 | 2 | 18 | 4 | 1 | 2.98 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 70 | 0 | 5 | 1 | 1.98 | .266 | 1.08 | 6.0 | 3.8 | 8.5 | 95.2 | 63 | 22 | 21 | 8 | 40 | 90 | 0 | 12 | 3 | 0 | 0 | 1 | 1 | 3.49 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 59 | 0 | 4 | 5 | 1.71 | .248 | 0.99 | 6.0 | 3.0 | 8.3 | 73.2 | 49 | 14 | 14 | 4 | 24 | 67 | 0 | 11 | 3 | 0 | 0 | 0 | 2 | 2.86 |
| RP | Capps, C.Capps, Carter # >> | 24 | 2015 | R | 84 | 40 | 0 | 4 | 6 | 4.43 | .289 | 1.22 | 8.6 | 2.6 | 8.4 | 42.2 | 40 | 21 | 21 | 6 | 12 | 39 | 0 | 7 | 3 | 0 | 0 | 0 | 2 | 3.86 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 26 | 0 | 2 | 1 | 1.15 | .223 | 0.86 | 5.8 | 2.0 | 7.5 | 31.1 | 20 | 4 | 4 | 1 | 7 | 26 | 0 | 7 | 0 | 0 | 0 | 0 | 3 | 2.42 |
| RP | Radatz, D.Radatz, Dick >> | 27 | 1964 | R | 37 | 4 | 0 | 1 | 0 | 7.11 | .406 | 2.05 | 12.0 | 7.5 | 7.5 | 6.1 | 8 | 5 | 5 | 3 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.33 |