| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 19 | 19 | 6 | 8 | 4.62 | .322 | 1.40 | 8.6 | 4.0 | 7.9 | 111.0 | 106 | 60 | 57 | 13 | 49 | 97 | 0 | 0 | 0 | 0 | 11 | 3 | 0 | 4.18 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 82 | 18 | 18 | 2 | 8 | 4.76 | .324 | 1.39 | 9.6 | 2.9 | 5.9 | 123.0 | 131 | 71 | 65 | 18 | 40 | 81 | 3 | 0 | 0 | 0 | 10 | 6 | 1 | 4.71 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 68 | 18 | 18 | 7 | 9 | 6.36 | .354 | 1.61 | 11.5 | 3.1 | 5.4 | 104.2 | 133 | 86 | 74 | 24 | 36 | 62 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 5.93 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 17 | 17 | 8 | 4 | 5.64 | .350 | 1.59 | 8.7 | 5.5 | 7.1 | 99.0 | 96 | 64 | 62 | 17 | 61 | 78 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 5.60 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 50 | 0 | 4 | 2 | 3.92 | .306 | 1.31 | 8.2 | 3.7 | 9.1 | 66.2 | 60 | 30 | 29 | 11 | 27 | 67 | 0 | 9 | 1 | 0 | 0 | 1 | 1 | 4.41 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 45 | 26 | 0 | 2 | 0 | 1.38 | .258 | 1.01 | 6.5 | 2.8 | 10.7 | 32.2 | 23 | 5 | 5 | 2 | 10 | 38 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 2.47 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 33 | 20 | 0 | 2 | 0 | 4.21 | .306 | 1.29 | 7.6 | 4.3 | 7.9 | 25.2 | 21 | 12 | 12 | 1 | 12 | 22 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.32 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 2 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 0.0 | 9.0 | 9.0 | 1.2 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |