| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 36 | 36 | 11 | 16 | 4.19 | .309 | 1.30 | 8.9 | 2.8 | 8.2 | 251.1 | 248 | 133 | 117 | 37 | 78 | 230 | 4 | 0 | 0 | 0 | 19 | 11 | 5 | 4.15 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 34 | 34 | 11 | 9 | 5.11 | .305 | 1.29 | 9.0 | 2.6 | 9.3 | 206.0 | 206 | 121 | 117 | 32 | 60 | 214 | 0 | 0 | 0 | 0 | 19 | 5 | 3 | 3.89 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 33 | 33 | 13 | 10 | 4.12 | .305 | 1.29 | 8.4 | 3.2 | 9.1 | 231.1 | 216 | 109 | 106 | 26 | 82 | 234 | 2 | 0 | 0 | 0 | 19 | 6 | 5 | 3.58 |
| SP | Harvey, M.Harvey, Matt # >> | 24 | 2013 | R | 75 | 33 | 33 | 10 | 14 | 4.90 | .318 | 1.38 | 10.0 | 2.4 | 9.4 | 222.1 | 247 | 130 | 121 | 27 | 60 | 231 | 9 | 0 | 0 | 1 | 13 | 4 | 5 | 3.36 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 77 | 31 | 31 | 13 | 15 | 4.80 | .326 | 1.43 | 8.9 | 4.0 | 6.1 | 189.1 | 187 | 105 | 101 | 26 | 83 | 128 | 1 | 0 | 0 | 1 | 14 | 5 | 6 | 4.83 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 88 | 0 | 5 | 8 | 2.58 | .260 | 1.03 | 7.0 | 2.3 | 9.7 | 115.0 | 89 | 38 | 33 | 11 | 29 | 124 | 0 | 6 | 4 | 0 | 0 | 3 | 0 | 2.92 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 76 | 0 | 5 | 4 | 4.23 | .303 | 1.29 | 7.8 | 3.9 | 10.8 | 76.2 | 66 | 39 | 36 | 13 | 33 | 91 | 0 | 13 | 4 | 0 | 0 | 1 | 0 | 4.17 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 46 | 0 | 1 | 3 | 3.22 | .304 | 1.29 | 8.8 | 2.9 | 9.4 | 50.1 | 49 | 18 | 18 | 10 | 16 | 52 | 0 | 6 | 3 | 0 | 0 | 1 | 0 | 4.54 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 75 | 71 | 0 | 1 | 1 | 3.93 | .299 | 1.23 | 6.5 | 4.8 | 8.8 | 36.2 | 26 | 17 | 16 | 5 | 19 | 35 | 0 | 4 | 1 | 0 | 0 | 2 | 5 | 4.61 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 69 | 37 | 0 | 6 | 3 | 3.38 | .316 | 1.38 | 8.5 | 4.2 | 6.9 | 34.2 | 32 | 16 | 13 | 2 | 16 | 26 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.65 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 63 | 16 | 0 | 3 | 0 | 4.30 | .318 | 1.40 | 9.0 | 3.8 | 6.3 | 60.2 | 60 | 30 | 29 | 10 | 25 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.02 |