| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 15 | 15 | 4 | 9 | 4.04 | .283 | 1.17 | 7.7 | 2.9 | 9.2 | 100.1 | 85 | 46 | 45 | 17 | 32 | 102 | 1 | 0 | 0 | 1 | 9 | 2 | 4 | 4.19 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 13 | 13 | 2 | 6 | 5.45 | .323 | 1.38 | 10.3 | 2.1 | 8.8 | 76.0 | 87 | 46 | 46 | 15 | 18 | 74 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.49 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 85 | 15 | 14 | 4 | 8 | 4.63 | .316 | 1.37 | 8.3 | 4.1 | 10.1 | 83.2 | 77 | 43 | 43 | 9 | 38 | 93 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.58 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 15 | 14 | 5 | 7 | 4.94 | .326 | 1.41 | 9.3 | 3.5 | 9.8 | 98.1 | 101 | 54 | 54 | 15 | 38 | 107 | 0 | 0 | 0 | 0 | 7 | 4 | 3 | 4.09 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 64 | 15 | 14 | 2 | 10 | 6.06 | .374 | 1.75 | 12.1 | 3.6 | 6.4 | 95.0 | 128 | 67 | 64 | 9 | 38 | 68 | 2 | 0 | 0 | 0 | 6 | 4 | 0 | 4.13 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 22 | 0 | 1 | 1 | 3.51 | .287 | 1.21 | 8.3 | 2.9 | 10.1 | 25.2 | 23 | 11 | 10 | 4 | 8 | 28 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 38 | 0 | 2 | 4 | 3.58 | .311 | 1.33 | 8.5 | 3.6 | 8.8 | 50.1 | 47 | 20 | 20 | 8 | 20 | 49 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 4.38 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 37 | 0 | 2 | 2 | 2.92 | .237 | 0.91 | 6.1 | 2.2 | 8.1 | 49.1 | 33 | 17 | 16 | 8 | 12 | 44 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.12 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 78 | 19 | 0 | 0 | 0 | 6.41 | .337 | 1.53 | 9.5 | 4.7 | 9.5 | 19.2 | 20 | 14 | 14 | 2 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.84 |