| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 14 | 14 | 8 | 3 | 2.14 | .253 | 0.97 | 6.4 | 2.4 | 9.6 | 92.2 | 65 | 25 | 22 | 6 | 25 | 98 | 1 | 0 | 0 | 1 | 10 | 4 | 0 | 2.66 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 14 | 14 | 7 | 3 | 3.18 | .264 | 1.06 | 6.5 | 3.1 | 6.2 | 76.1 | 55 | 27 | 27 | 11 | 26 | 52 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 4.58 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 83 | 14 | 14 | 6 | 6 | 4.09 | .291 | 1.17 | 8.2 | 2.4 | 5.9 | 103.1 | 94 | 51 | 47 | 22 | 27 | 68 | 3 | 0 | 0 | 1 | 9 | 6 | 0 | 5.42 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 15 | 14 | 4 | 5 | 4.43 | .301 | 1.26 | 8.3 | 3.0 | 8.3 | 69.0 | 64 | 38 | 34 | 9 | 23 | 64 | 0 | 0 | 0 | 0 | 2 | 2 | 3 | 3.93 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 33 | 0 | 1 | 2 | 1.74 | .271 | 1.11 | 6.8 | 3.3 | 10.1 | 41.1 | 31 | 8 | 8 | 2 | 15 | 46 | 0 | 11 | 0 | 0 | 0 | 0 | 3 | 2.49 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 37 | 0 | 1 | 4 | 2.31 | .235 | 0.88 | 5.3 | 2.7 | 10.0 | 46.2 | 27 | 12 | 12 | 4 | 14 | 51 | 0 | 6 | 3 | 0 | 0 | 2 | 1 | 2.96 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 30 | 0 | 4 | 0 | 4.14 | .287 | 1.19 | 6.8 | 4.0 | 9.0 | 41.1 | 31 | 20 | 19 | 9 | 18 | 41 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 5.24 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 73 | 25 | 0 | 1 | 2 | 2.48 | .246 | 0.95 | 6.8 | 2.0 | 10.7 | 32.2 | 24 | 9 | 9 | 5 | 7 | 38 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 67 | 15 | 0 | 1 | 1 | 3.57 | .329 | 1.42 | 10.1 | 3.2 | 7.4 | 17.2 | 19 | 7 | 7 | 0 | 6 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.59 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 58 | 10 | 0 | 0 | 1 | 3.07 | .290 | 1.16 | 7.7 | 3.2 | 9.0 | 14.2 | 12 | 5 | 5 | 3 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.07 |