| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 30 | 30 | 16 | 9 | 3.15 | .292 | 1.21 | 7.7 | 3.2 | 7.7 | 200.0 | 170 | 74 | 70 | 19 | 72 | 170 | 1 | 0 | 0 | 1 | 20 | 6 | 12 | 3.71 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 29 | 29 | 10 | 6 | 3.15 | .295 | 1.23 | 8.0 | 3.1 | 9.2 | 188.1 | 167 | 69 | 66 | 23 | 65 | 192 | 1 | 0 | 0 | 0 | 19 | 4 | 0 | 3.65 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 73 | 29 | 29 | 10 | 8 | 3.30 | .281 | 1.16 | 8.2 | 2.3 | 6.6 | 190.2 | 173 | 70 | 70 | 20 | 48 | 139 | 0 | 0 | 0 | 0 | 23 | 3 | 1 | 3.71 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 67 | 0 | 7 | 4 | 2.25 | .237 | 0.86 | 5.8 | 2.0 | 9.3 | 72.0 | 46 | 18 | 18 | 8 | 16 | 74 | 0 | 41 | 6 | 0 | 0 | 5 | 1 | 3.26 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 57 | 0 | 1 | 4 | 3.22 | .251 | 1.01 | 5.4 | 3.7 | 10.4 | 58.2 | 35 | 21 | 21 | 9 | 24 | 67 | 0 | 8 | 5 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 87 | 82 | 0 | 8 | 2 | 3.95 | .277 | 1.13 | 7.1 | 3.1 | 8.9 | 95.2 | 75 | 48 | 42 | 19 | 33 | 94 | 0 | 2 | 2 | 0 | 0 | 2 | 4 | 4.73 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 58 | 0 | 4 | 3 | 2.52 | .248 | 0.97 | 7.7 | 1.2 | 8.6 | 60.2 | 51 | 20 | 17 | 5 | 8 | 57 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 2.63 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 25 | 0 | 4 | 1 | 5.26 | .342 | 1.52 | 7.9 | 6.1 | 11.9 | 25.2 | 22 | 15 | 15 | 4 | 17 | 33 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.60 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 66 | 27 | 0 | 1 | 1 | 4.31 | .293 | 1.21 | 6.1 | 4.9 | 7.3 | 31.1 | 21 | 18 | 15 | 4 | 17 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.81 |