| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 93 | 14 | 14 | 5 | 3 | 3.68 | .275 | 1.14 | 7.5 | 2.8 | 5.9 | 88.0 | 73 | 38 | 36 | 14 | 27 | 58 | 3 | 0 | 0 | 1 | 9 | 0 | 0 | 4.67 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 73 | 13 | 13 | 3 | 5 | 5.72 | .362 | 1.67 | 11.3 | 3.9 | 7.9 | 67.2 | 84 | 47 | 43 | 14 | 29 | 59 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 5.34 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 32 | 0 | 0 | 3 | 3.30 | .274 | 1.13 | 7.8 | 2.4 | 10.8 | 30.0 | 26 | 11 | 11 | 2 | 8 | 36 | 0 | 18 | 0 | 0 | 0 | 0 | 2 | 2.27 |
| SU | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 90 | 28 | 0 | 0 | 0 | 1.22 | .218 | 0.81 | 4.6 | 2.7 | 10.5 | 37.0 | 19 | 5 | 5 | 1 | 11 | 43 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.00 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 32 | 0 | 2 | 3 | 4.20 | .328 | 1.43 | 10.5 | 2.4 | 11.4 | 30.0 | 35 | 14 | 14 | 5 | 8 | 38 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.53 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 32 | 0 | 4 | 2 | 3.93 | .295 | 1.19 | 7.1 | 3.7 | 9.3 | 34.1 | 27 | 15 | 15 | 6 | 14 | 35 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 4.65 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 76 | 23 | 0 | 2 | 0 | 5.25 | .301 | 1.29 | 8.3 | 3.4 | 7.5 | 24.0 | 22 | 14 | 14 | 5 | 9 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.17 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 18 | 0 | 0 | 0 | 2.49 | .286 | 1.20 | 6.9 | 4.3 | 10.3 | 21.2 | 16 | 6 | 6 | 1 | 10 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.76 |