| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 2 | 4 | 6.14 | .380 | 1.74 | 12.4 | 3.4 | 8.7 | 29.1 | 40 | 22 | 20 | 1 | 11 | 28 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 2.97 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 5 | 5 | 1 | 2 | 5.68 | .326 | 1.45 | 9.3 | 4.1 | 8.7 | 31.2 | 32 | 20 | 20 | 6 | 14 | 30 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.94 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 5 | 5 | 1 | 2 | 7.42 | .364 | 1.71 | 12.6 | 3.0 | 8.1 | 30.1 | 42 | 25 | 25 | 7 | 10 | 27 | 0 | 0 | 0 | 0 | 1 | 0 | 5 | 5.23 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 5 | 5 | 0 | 2 | 6.48 | .401 | 1.98 | 13.1 | 4.9 | 4.9 | 33.1 | 48 | 30 | 24 | 6 | 18 | 18 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 6.00 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 11 | 0 | 0 | 0 | 0.00 | .245 | 0.97 | 3.0 | 6.0 | 14.3 | 12.1 | 4 | 0 | 0 | 0 | 8 | 19 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 1.83 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 13 | 0 | 1 | 3 | 4.58 | .264 | 1.08 | 6.9 | 3.2 | 5.8 | 17.2 | 13 | 9 | 9 | 2 | 6 | 11 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.29 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 14 | 0 | 1 | 0 | 9.00 | .373 | 1.79 | 14.1 | 1.9 | 9.0 | 14.0 | 22 | 14 | 14 | 7 | 3 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 8.14 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 15 | 0 | 0 | 1 | 7.36 | .313 | 1.30 | 10.9 | 1.3 | 6.4 | 14.2 | 17 | 12 | 12 | 5 | 2 | 10 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.86 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 14 | 0 | 1 | 0 | 0.66 | .163 | 0.59 | 3.5 | 2.1 | 11.8 | 13.2 | 5 | 1 | 1 | 1 | 3 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.08 |