| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 33 | 33 | 10 | 8 | 4.23 | .291 | 1.21 | 8.5 | 2.4 | 7.8 | 206.1 | 194 | 100 | 97 | 25 | 55 | 178 | 6 | 0 | 0 | 0 | 18 | 5 | 3 | 3.72 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 32 | 32 | 15 | 8 | 4.71 | .312 | 1.34 | 8.7 | 3.5 | 9.2 | 181.2 | 174 | 97 | 95 | 31 | 70 | 185 | 1 | 0 | 0 | 0 | 16 | 3 | 2 | 4.39 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 32 | 32 | 13 | 8 | 5.28 | .327 | 1.44 | 9.2 | 3.8 | 6.9 | 172.0 | 176 | 106 | 101 | 25 | 72 | 131 | 1 | 0 | 0 | 1 | 15 | 3 | 5 | 4.67 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 84 | 0 | 6 | 8 | 5.22 | .342 | 1.55 | 10.9 | 3.1 | 7.0 | 100.0 | 121 | 62 | 58 | 18 | 34 | 78 | 0 | 29 | 10 | 0 | 0 | 1 | 3 | 4.83 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 89 | 0 | 4 | 7 | 4.20 | .327 | 1.45 | 9.6 | 3.6 | 8.9 | 98.2 | 104 | 47 | 46 | 12 | 39 | 97 | 0 | 7 | 6 | 0 | 0 | 1 | 0 | 3.84 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 75 | 0 | 7 | 4 | 5.38 | .321 | 1.39 | 8.5 | 4.0 | 8.4 | 98.2 | 93 | 60 | 59 | 14 | 44 | 91 | 0 | 0 | 2 | 0 | 0 | 3 | 0 | 4.44 |