| SP | Santana, J.Santana, Johan † >> | 26 | 2005 | L | 97 | 51 | 51 | 35 | 10 | 2.13 | .249 | 0.97 | 6.7 | 2.1 | 8.6 | 396.1 | 295 | 105 | 94 | 19 | 91 | 378 | 19 | 0 | 0 | 3 | 0 | 9 | 9 | 2.47 |
| SP | Saberhagen, B.Saberhagen, Bret # >> | 35 | 1999 | R | 70 | 29 | 25 | 8 | 8 | 4.75 | .306 | 1.30 | 10.0 | 1.8 | 5.6 | 149.2 | 165 | 88 | 79 | 19 | 30 | 93 | 1 | 0 | 0 | 1 | 0 | 3 | 4 | 4.07 |
| SP | Tudor, J.Tudor, John # >> | 34 | 1988 | L | 67 | 44 | 44 | 13 | 14 | 5.38 | .345 | 1.57 | 11.2 | 3.0 | 5.4 | 237.1 | 294 | 146 | 142 | 29 | 79 | 141 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.43 |
| SP | Sanford, J.Sanford, Jack >> | 34 | 1963 | R | 62 | 3 | 0 | 0 | 0 | 54.00 | .722 | 7.80 | 108.0 | 9.0 | 9.0 | 1.2 | 12 | 10 | 10 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17.00 |
| RP | Hermanson, D.Hermanson, Dustin >> | 33 | 2005 | R | 75 | 85 | 0 | 6 | 4 | 4.24 | .320 | 1.41 | 9.6 | 3.2 | 5.6 | 91.1 | 97 | 50 | 43 | 5 | 32 | 57 | 0 | 3 | 4 | 0 | 0 | 0 | 5 | 3.52 |
| RP | Maddux, G.Maddux, Greg # >> | 38 | 2004 | R | 61 | 39 | 0 | 4 | 0 | 4.43 | .313 | 1.34 | 9.7 | 2.4 | 6.2 | 91.1 | 98 | 47 | 45 | 13 | 24 | 63 | 0 | 3 | 0 | 0 | 0 | 3 | 2 | 4.36 |
| SU | Guardado, E.Guardado, Eddie >> | 35 | 2005 | L | 68 | 69 | 0 | 3 | 2 | 4.15 | .314 | 1.35 | 8.4 | 3.7 | 7.6 | 78.0 | 73 | 40 | 36 | 10 | 32 | 66 | 0 | 5 | 3 | 0 | 0 | 2 | 1 | 4.28 |
| SP | Billingham, J.Billingham, Jack >> | 30 | 1973 | R | 73 | 12 | 5 | 0 | 4 | 10.05 | .416 | 2.14 | 15.1 | 4.4 | 6.1 | 31.1 | 52 | 43 | 35 | 6 | 15 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.61 |