| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 81 | 28 | 28 | 11 | 5 | 4.34 | .293 | 1.23 | 7.5 | 3.6 | 7.5 | 163.2 | 136 | 80 | 79 | 22 | 66 | 136 | 0 | 0 | 0 | 0 | 17 | 1 | 6 | 4.32 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 28 | 28 | 14 | 7 | 3.27 | .260 | 1.02 | 7.1 | 2.1 | 4.4 | 200.2 | 158 | 77 | 73 | 18 | 46 | 98 | 5 | 0 | 0 | 1 | 19 | 7 | 1 | 3.99 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 28 | 28 | 11 | 5 | 4.29 | .325 | 1.42 | 7.6 | 5.2 | 8.7 | 163.2 | 137 | 79 | 78 | 15 | 95 | 157 | 1 | 0 | 0 | 1 | 16 | 4 | 2 | 4.09 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 62 | 0 | 5 | 4 | 1.75 | .250 | 0.99 | 6.4 | 2.5 | 8.1 | 72.0 | 51 | 14 | 14 | 2 | 20 | 65 | 0 | 31 | 2 | 0 | 0 | 1 | 0 | 2.43 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 74 | 0 | 4 | 5 | 3.38 | .285 | 1.15 | 7.0 | 3.4 | 7.5 | 88.0 | 68 | 33 | 33 | 11 | 33 | 73 | 0 | 2 | 5 | 0 | 0 | 4 | 0 | 4.23 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 64 | 0 | 2 | 4 | 3.82 | .300 | 1.26 | 8.1 | 3.3 | 8.6 | 68.1 | 61 | 31 | 29 | 5 | 25 | 65 | 0 | 1 | 2 | 0 | 0 | 2 | 5 | 3.24 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 45 | 0 | 5 | 3 | 3.71 | .278 | 1.12 | 6.0 | 4.1 | 8.5 | 51.0 | 34 | 23 | 21 | 8 | 23 | 48 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.63 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 35 | 0 | 4 | 1 | 2.88 | .280 | 1.14 | 7.1 | 3.2 | 7.9 | 34.1 | 27 | 12 | 11 | 5 | 12 | 30 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 4.29 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 31 | 0 | 1 | 1 | 2.32 | .264 | 1.08 | 6.2 | 3.6 | 8.4 | 42.2 | 29 | 11 | 11 | 2 | 17 | 39 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 2.98 |