| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 9 | 10 | 4.02 | .286 | 1.18 | 8.4 | 2.2 | 8.5 | 159.0 | 148 | 72 | 71 | 26 | 39 | 150 | 2 | 0 | 0 | 0 | 15 | 4 | 0 | 4.05 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 23 | 21 | 8 | 8 | 4.63 | .315 | 1.34 | 8.8 | 3.3 | 8.2 | 130.1 | 127 | 70 | 67 | 15 | 48 | 118 | 0 | 0 | 0 | 0 | 11 | 5 | 7 | 3.91 |
| CL | Hader, J.Hader, Josh # $$ >> | 24 | 2018 | L | 93 | 52 | 0 | 3 | 8 | 4.50 | .298 | 1.28 | 7.0 | 4.5 | 8.5 | 58.0 | 45 | 29 | 29 | 7 | 29 | 55 | 0 | 26 | 4 | 0 | 0 | 0 | 0 | 4.17 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 50 | 0 | 1 | 2 | 2.79 | .316 | 1.39 | 8.4 | 4.1 | 8.1 | 48.1 | 45 | 18 | 15 | 3 | 22 | 43 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 46 | 0 | 6 | 1 | 1.60 | .228 | 0.89 | 5.2 | 2.9 | 7.7 | 50.2 | 29 | 10 | 9 | 3 | 16 | 43 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.02 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 55 | 0 | 3 | 4 | 4.50 | .299 | 1.24 | 7.3 | 3.8 | 8.2 | 54.0 | 44 | 27 | 27 | 7 | 23 | 49 | 0 | 1 | 5 | 0 | 0 | 2 | 2 | 4.26 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 4 | 0 | 0 | 0 | 3.18 | .190 | 0.71 | 3.6 | 3.6 | 10.8 | 5.2 | 2 | 2 | 2 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.80 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 3 | 0 | 0 | 0 | 3.86 | .300 | 1.29 | 9.0 | 4.5 | 13.5 | 2.1 | 2 | 1 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.50 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 13 | 0 | 0 | 0 | 5.80 | .345 | 1.56 | 9.7 | 4.5 | 6.5 | 54.1 | 58 | 36 | 35 | 7 | 27 | 39 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.80 |