| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 18 | 18 | 6 | 5 | 4.53 | .333 | 1.49 | 9.6 | 3.9 | 9.5 | 105.1 | 112 | 61 | 53 | 12 | 45 | 111 | 0 | 0 | 0 | 0 | 10 | 1 | 3 | 3.69 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 18 | 18 | 3 | 6 | 5.03 | .357 | 1.61 | 8.6 | 5.9 | 9.2 | 73.1 | 70 | 43 | 41 | 11 | 48 | 75 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 5.04 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 67 | 19 | 18 | 5 | 5 | 5.31 | .347 | 1.57 | 10.1 | 4.2 | 9.5 | 101.2 | 113 | 71 | 60 | 16 | 47 | 107 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.40 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 51 | 0 | 4 | 1 | 4.34 | .339 | 1.54 | 9.1 | 4.8 | 9.3 | 64.1 | 65 | 37 | 31 | 7 | 34 | 66 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 50 | 0 | 2 | 2 | 2.26 | .260 | 1.02 | 6.6 | 2.7 | 10.7 | 63.2 | 46 | 16 | 16 | 5 | 19 | 75 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2.65 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 42 | 0 | 4 | 1 | 4.65 | .322 | 1.40 | 7.7 | 5.2 | 11.7 | 40.2 | 34 | 24 | 21 | 8 | 23 | 52 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.80 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 30 | 0 | 2 | 1 | 2.56 | .256 | 1.03 | 4.7 | 4.7 | 9.0 | 38.2 | 20 | 14 | 11 | 2 | 20 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.26 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 22 | 0 | 3 | 1 | 1.24 | .202 | 0.76 | 5.3 | 1.6 | 11.8 | 29.0 | 17 | 4 | 4 | 2 | 5 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.79 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 33 | 0 | 2 | 3 | 4.50 | .283 | 1.16 | 8.1 | 2.4 | 10.9 | 38.0 | 34 | 20 | 19 | 9 | 10 | 46 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 4.53 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 92 | 31 | 0 | 1 | 5 | 3.97 | .306 | 1.32 | 7.4 | 4.5 | 10.1 | 34.0 | 28 | 17 | 15 | 4 | 17 | 38 | 0 | 13 | 2 | 0 | 0 | 0 | 0 | 3.79 |