| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 93 | 19 | 19 | 8 | 9 | 3.28 | .296 | 1.23 | 6.7 | 4.4 | 8.5 | 131.2 | 98 | 51 | 48 | 15 | 64 | 124 | 2 | 0 | 0 | 0 | 15 | 4 | 2 | 4.15 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 18 | 18 | 5 | 11 | 4.01 | .299 | 1.27 | 9.4 | 2.0 | 6.1 | 130.1 | 136 | 63 | 58 | 18 | 29 | 88 | 2 | 0 | 0 | 1 | 10 | 2 | 2 | 4.16 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 53 | 18 | 18 | 5 | 8 | 6.68 | .373 | 1.76 | 9.3 | 6.6 | 9.7 | 94.1 | 97 | 75 | 70 | 19 | 69 | 101 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 5.74 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 83 | 18 | 18 | 5 | 7 | 6.16 | .355 | 1.62 | 11.6 | 3.0 | 8.1 | 95.0 | 122 | 71 | 65 | 18 | 32 | 86 | 0 | 0 | 0 | 0 | 7 | 3 | 4 | 4.76 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 18 | 17 | 4 | 7 | 5.55 | .347 | 1.54 | 9.9 | 4.0 | 6.7 | 110.1 | 121 | 77 | 68 | 21 | 49 | 82 | 1 | 0 | 0 | 0 | 6 | 6 | 0 | 5.49 |
| RP | Benitez, A.Benitez, Armando >> | 27 | 1999 | R | 57 | 48 | 0 | 4 | 0 | 3.51 | .337 | 1.47 | 6.8 | 6.6 | 10.0 | 56.1 | 42 | 22 | 22 | 7 | 41 | 62 | 0 | 1 | 1 | 0 | 0 | 3 | 3 | 4.77 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 37 | 0 | 1 | 2 | 2.22 | .270 | 1.07 | 8.3 | 1.5 | 11.3 | 48.2 | 44 | 14 | 12 | 7 | 8 | 60 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.02 |
| CL | Edwards, C.Edwards, Carl † >> | 24 | 2016 | R | 93 | 26 | 0 | 1 | 0 | 1.30 | .231 | 0.90 | 4.0 | 4.3 | 12.3 | 27.2 | 12 | 4 | 4 | 1 | 13 | 37 | 0 | 20 | 2 | 0 | 0 | 0 | 2 | 2.19 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 27 | 0 | 2 | 0 | 3.38 | .338 | 1.53 | 8.1 | 5.9 | 14.0 | 29.1 | 26 | 11 | 11 | 0 | 19 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1.86 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 24 | 0 | 1 | 3 | 3.63 | .323 | 1.39 | 7.8 | 4.9 | 11.0 | 22.1 | 19 | 11 | 9 | 4 | 12 | 27 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 4.68 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 66 | 16 | 0 | 0 | 1 | 2.61 | .225 | 0.82 | 5.4 | 2.3 | 10.8 | 20.2 | 12 | 6 | 6 | 3 | 5 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.45 |