| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 39 | 39 | 14 | 11 | 3.14 | .280 | 1.14 | 7.9 | 2.4 | 10.8 | 257.2 | 226 | 99 | 90 | 30 | 68 | 309 | 1 | 0 | 0 | 1 | 26 | 7 | 0 | 2.99 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 89 | 38 | 38 | 17 | 9 | 3.47 | .284 | 1.17 | 6.7 | 3.9 | 9.4 | 238.1 | 176 | 92 | 92 | 28 | 103 | 248 | 0 | 0 | 0 | 0 | 22 | 5 | 6 | 3.81 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 83 | 36 | 36 | 17 | 15 | 4.56 | .308 | 1.32 | 9.0 | 2.9 | 6.4 | 266.1 | 265 | 145 | 135 | 30 | 86 | 188 | 14 | 0 | 0 | 4 | 15 | 5 | 6 | 4.08 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 87 | 35 | 35 | 10 | 8 | 5.63 | .333 | 1.47 | 10.4 | 2.9 | 6.3 | 179.0 | 206 | 115 | 112 | 30 | 57 | 125 | 0 | 0 | 0 | 0 | 6 | 5 | 2 | 4.82 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 91 | 0 | 10 | 9 | 4.09 | .286 | 1.15 | 6.8 | 3.6 | 8.1 | 105.2 | 79 | 51 | 48 | 17 | 42 | 94 | 0 | 3 | 7 | 0 | 0 | 6 | 0 | 4.69 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 85 | 0 | 2 | 3 | 4.48 | .301 | 1.28 | 8.6 | 2.9 | 9.9 | 92.1 | 88 | 47 | 46 | 13 | 30 | 101 | 0 | 0 | 5 | 0 | 0 | 1 | 1 | 3.65 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 73 | 46 | 0 | 1 | 3 | 4.41 | .319 | 1.41 | 8.6 | 4.0 | 9.9 | 49.0 | 47 | 24 | 24 | 5 | 22 | 54 | 0 | 3 | 0 | 0 | 0 | 0 | 4 | 3.47 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 64 | 48 | 0 | 3 | 1 | 3.31 | .317 | 1.35 | 7.1 | 5.3 | 9.0 | 51.2 | 40 | 21 | 19 | 6 | 30 | 51 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.41 |
| CL | Street, H.Street, Huston † $ >> | 29 | 2012 | R | 96 | 72 | 0 | 9 | 6 | 2.77 | .242 | 0.92 | 5.9 | 2.4 | 9.4 | 81.1 | 53 | 25 | 25 | 7 | 22 | 85 | 0 | 37 | 5 | 0 | 0 | 3 | 0 | 2.95 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 1 | 0 | 0 | 0 | 0.00 | .500 | 3.00 | - | - | - | 0.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |