| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 33 | 33 | 17 | 6 | 3.20 | .259 | 1.04 | 7.0 | 2.3 | 9.5 | 222.0 | 173 | 80 | 79 | 24 | 57 | 235 | 2 | 0 | 0 | 1 | 21 | 3 | 0 | 3.10 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 32 | 32 | 13 | 12 | 4.14 | .305 | 1.29 | 8.4 | 3.2 | 9.0 | 215.0 | 201 | 102 | 99 | 29 | 77 | 214 | 1 | 0 | 0 | 0 | 18 | 5 | 5 | 3.91 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 84 | 32 | 32 | 15 | 7 | 3.66 | .301 | 1.25 | 7.3 | 3.9 | 7.9 | 196.2 | 159 | 81 | 80 | 25 | 86 | 173 | 0 | 0 | 0 | 0 | 19 | 9 | 4 | 4.35 |
| SP | Gooden, D.Gooden, Dwight † # >> | 21 | 1985 | R | 77 | 31 | 31 | 21 | 5 | 3.26 | .283 | 1.17 | 8.4 | 2.2 | 8.4 | 226.1 | 210 | 85 | 82 | 20 | 54 | 211 | 7 | 0 | 0 | 2 | 20 | 4 | 3 | 3.05 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 30 | 30 | 15 | 11 | 4.46 | .299 | 1.26 | 8.3 | 3.1 | 6.1 | 216.0 | 199 | 108 | 107 | 37 | 74 | 147 | 9 | 0 | 0 | 2 | 14 | 3 | 1 | 4.94 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 87 | 0 | 8 | 3 | 2.85 | .242 | 0.96 | 6.6 | 2.0 | 10.2 | 117.0 | 86 | 39 | 37 | 9 | 26 | 133 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 2.39 |
| RP | Miller, A.Miller, Andrew # >> | 31 | 2016 | L | 90 | 74 | 0 | 7 | 5 | 3.98 | .289 | 1.19 | 8.4 | 2.3 | 11.1 | 86.0 | 80 | 45 | 38 | 12 | 22 | 106 | 0 | 13 | 2 | 0 | 0 | 3 | 1 | 3.22 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 57 | 0 | 4 | 2 | 2.77 | .246 | 0.97 | 7.5 | 1.2 | 8.9 | 68.1 | 57 | 23 | 21 | 11 | 9 | 67 | 0 | 14 | 3 | 0 | 0 | 1 | 0 | 3.57 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 83 | 34 | 0 | 1 | 4 | 3.82 | .294 | 1.22 | 9.0 | 2.2 | 11.7 | 37.2 | 37 | 16 | 16 | 6 | 9 | 48 | 0 | 5 | 4 | 0 | 0 | 1 | 2 | 3.32 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 29 | 0 | 1 | 1 | 4.08 | .301 | 1.29 | 8.0 | 3.9 | 10.0 | 28.2 | 25 | 14 | 13 | 3 | 12 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.46 |