| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 34 | 34 | 14 | 10 | 3.05 | .278 | 1.14 | 7.9 | 2.4 | 4.8 | 259.1 | 226 | 100 | 88 | 27 | 69 | 138 | 14 | 0 | 0 | 3 | 23 | 4 | 7 | 4.14 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 36 | 36 | 13 | 15 | 3.86 | .287 | 1.19 | 7.2 | 3.5 | 8.7 | 217.0 | 174 | 100 | 93 | 32 | 85 | 210 | 3 | 0 | 0 | 1 | 22 | 3 | 3 | 4.20 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 34 | 34 | 16 | 13 | 3.49 | .277 | 1.14 | 8.0 | 2.3 | 5.1 | 235.0 | 208 | 103 | 91 | 18 | 60 | 133 | 11 | 0 | 0 | 2 | 22 | 2 | 4 | 3.66 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 77 | 31 | 31 | 13 | 12 | 5.07 | .300 | 1.26 | 9.4 | 1.9 | 5.1 | 199.0 | 208 | 122 | 112 | 24 | 43 | 112 | 7 | 0 | 0 | 1 | 11 | 5 | 3 | 4.17 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 87 | 0 | 6 | 3 | 3.16 | .291 | 1.18 | 5.5 | 5.2 | 10.3 | 94.0 | 57 | 37 | 33 | 8 | 54 | 108 | 0 | 4 | 4 | 0 | 0 | 5 | 5 | 3.69 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 56 | 0 | 4 | 3 | 3.60 | .316 | 1.34 | 8.2 | 3.9 | 8.9 | 65.0 | 59 | 27 | 26 | 5 | 28 | 64 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 3.46 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 26 | 0 | 1 | 0 | 4.99 | .366 | 1.60 | 9.9 | 4.8 | 8.7 | 30.2 | 33 | 21 | 17 | 1 | 16 | 29 | 0 | 1 | 1 | 0 | 0 | 4 | 2 | 3.50 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 11 | 0 | 0 | 1 | 5.11 | .288 | 1.22 | 9.0 | 2.3 | 7.5 | 12.1 | 12 | 10 | 7 | 3 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 69 | 0 | 6 | 3 | 3.29 | .283 | 1.16 | 6.0 | 4.4 | 7.9 | 82.0 | 55 | 31 | 30 | 3 | 40 | 72 | 0 | 12 | 3 | 0 | 0 | 2 | 4 | 3.26 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 29 | 0 | 3 | 1 | 3.77 | .321 | 1.42 | 7.8 | 4.9 | 4.9 | 31.0 | 27 | 13 | 13 | 2 | 17 | 17 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.39 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 37 | 0 | 3 | 2 | 4.22 | .319 | 1.36 | 9.0 | 3.4 | 9.4 | 42.2 | 42 | 20 | 20 | 5 | 16 | 44 | 0 | 4 | 1 | 0 | 0 | 2 | 1 | 3.74 |