| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 8 | 4 | 2.43 | .268 | 1.07 | 6.5 | 3.2 | 9.0 | 107.1 | 77 | 29 | 29 | 8 | 38 | 107 | 0 | 0 | 0 | 0 | 14 | 3 | 0 | 3.12 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 16 | 16 | 5 | 4 | 4.12 | .273 | 1.13 | 8.1 | 2.1 | 5.3 | 109.1 | 98 | 60 | 50 | 15 | 25 | 64 | 1 | 0 | 0 | 0 | 9 | 0 | 2 | 4.30 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 33 | 0 | 1 | 3 | 4.67 | .297 | 1.24 | 6.4 | 5.0 | 8.7 | 34.2 | 24 | 19 | 18 | 4 | 19 | 33 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 4.35 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 37 | 0 | 4 | 1 | 4.30 | .327 | 1.46 | 7.3 | 6.1 | 7.8 | 37.2 | 30 | 21 | 18 | 6 | 25 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.41 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 21 | 0 | 2 | 0 | 2.74 | .296 | 1.22 | 7.4 | 3.5 | 11.0 | 23.0 | 19 | 7 | 7 | 2 | 9 | 28 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.00 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 78 | 16 | 0 | 2 | 1 | 2.45 | .337 | 1.53 | 8.5 | 5.5 | 7.5 | 18.1 | 17 | 8 | 5 | 0 | 11 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.17 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 21 | 0 | 2 | 2 | 5.14 | .344 | 1.57 | 9.4 | 4.7 | 7.7 | 21.0 | 22 | 14 | 12 | 6 | 11 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.57 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 47 | 7 | 0 | 4 | 0 | 5.64 | .309 | 1.34 | 7.0 | 5.3 | 7.4 | 22.1 | 17 | 14 | 14 | 5 | 13 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.09 |