| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 34 | 34 | 11 | 12 | 3.16 | .297 | 1.24 | 7.2 | 4.0 | 7.4 | 225.0 | 179 | 88 | 79 | 21 | 100 | 185 | 1 | 0 | 0 | 0 | 26 | 6 | 4 | 3.98 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 35 | 35 | 12 | 11 | 3.82 | .295 | 1.24 | 9.0 | 2.2 | 5.7 | 245.0 | 245 | 110 | 104 | 18 | 59 | 155 | 2 | 0 | 0 | 0 | 18 | 3 | 3 | 3.45 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 33 | 33 | 19 | 10 | 3.61 | .296 | 1.24 | 6.5 | 4.7 | 4.2 | 229.1 | 166 | 100 | 92 | 15 | 119 | 107 | 7 | 0 | 0 | 2 | 22 | 4 | 8 | 4.53 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 68 | 0 | 6 | 8 | 2.71 | .258 | 1.03 | 5.1 | 4.2 | 8.6 | 73.0 | 41 | 22 | 22 | 7 | 34 | 70 | 0 | 41 | 3 | 0 | 0 | 1 | 2 | 3.77 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 86 | 0 | 6 | 4 | 2.65 | .251 | 0.98 | 5.6 | 3.3 | 9.1 | 105.1 | 65 | 32 | 31 | 11 | 38 | 106 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.51 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 64 | 0 | 5 | 3 | 3.39 | .274 | 1.13 | 6.5 | 3.8 | 8.0 | 71.2 | 51 | 30 | 27 | 6 | 30 | 63 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.59 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 28 | 0 | 5 | 0 | 2.94 | .261 | 1.02 | 7.3 | 1.9 | 8.1 | 52.0 | 42 | 18 | 17 | 4 | 11 | 47 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2.94 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 25 | 0 | 0 | 0 | 2.70 | .286 | 1.20 | 5.2 | 5.7 | 7.9 | 33.1 | 19 | 11 | 10 | 2 | 21 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.94 |