| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 10 | 4 | 2.38 | .254 | 1.01 | 6.9 | 2.2 | 8.9 | 144.0 | 110 | 43 | 38 | 15 | 35 | 142 | 1 | 0 | 0 | 1 | 17 | 2 | 0 | 3.15 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 20 | 20 | 9 | 5 | 6.34 | .338 | 1.51 | 10.7 | 3.0 | 8.3 | 120.2 | 142 | 86 | 85 | 10 | 40 | 111 | 1 | 0 | 0 | 1 | 6 | 3 | 5 | 3.31 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 19 | 19 | 8 | 6 | 4.28 | .296 | 1.20 | 8.7 | 2.2 | 7.7 | 132.1 | 127 | 66 | 63 | 17 | 32 | 113 | 1 | 0 | 0 | 1 | 11 | 8 | 2 | 3.87 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 20 | 19 | 3 | 12 | 5.38 | .324 | 1.38 | 9.3 | 3.1 | 5.4 | 115.1 | 119 | 74 | 69 | 19 | 40 | 69 | 6 | 0 | 0 | 2 | 6 | 7 | 2 | 5.17 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 56 | 0 | 7 | 1 | 2.53 | .292 | 1.21 | 6.5 | 4.4 | 6.9 | 89.0 | 64 | 29 | 25 | 9 | 44 | 68 | 0 | 5 | 5 | 0 | 0 | 2 | 0 | 4.34 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 46 | 0 | 6 | 4 | 4.27 | .325 | 1.39 | 7.3 | 5.4 | 9.3 | 52.2 | 42 | 25 | 25 | 4 | 31 | 54 | 0 | 6 | 3 | 0 | 0 | 3 | 0 | 3.88 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 34 | 0 | 2 | 4 | 2.61 | .275 | 1.14 | 7.0 | 3.3 | 11.4 | 41.1 | 32 | 12 | 12 | 5 | 15 | 52 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.15 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 19 | 0 | 0 | 0 | 4.15 | .309 | 1.34 | 6.9 | 5.6 | 6.0 | 21.2 | 16 | 10 | 10 | 2 | 13 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.76 |