| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 21 | 21 | 8 | 9 | 3.41 | .261 | 1.04 | 6.9 | 2.5 | 7.5 | 161.0 | 124 | 66 | 61 | 15 | 44 | 135 | 7 | 0 | 0 | 1 | 11 | 3 | 2 | 3.41 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 19 | 19 | 8 | 8 | 5.74 | .326 | 1.43 | 9.6 | 3.4 | 5.3 | 106.2 | 113 | 70 | 68 | 17 | 40 | 62 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 5.10 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 19 | 19 | 7 | 8 | 3.97 | .291 | 1.20 | 9.1 | 1.7 | 4.9 | 131.1 | 132 | 65 | 58 | 15 | 25 | 72 | 6 | 0 | 0 | 1 | 10 | 5 | 3 | 4.08 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 19 | 19 | 6 | 9 | 5.24 | .346 | 1.54 | 10.4 | 3.5 | 5.3 | 120.1 | 139 | 84 | 70 | 13 | 46 | 71 | 3 | 0 | 0 | 0 | 7 | 6 | 1 | 4.53 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 47 | 0 | 1 | 3 | 5.15 | .294 | 1.21 | 7.1 | 3.9 | 8.4 | 57.2 | 45 | 33 | 33 | 11 | 25 | 53 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 5.07 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 37 | 0 | 4 | 2 | 2.87 | .343 | 1.54 | 9.5 | 4.6 | 8.0 | 37.2 | 39 | 14 | 12 | 3 | 19 | 33 | 0 | 15 | 2 | 0 | 0 | 1 | 2 | 3.89 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 37 | 0 | 1 | 2 | 4.23 | .295 | 1.25 | 8.0 | 3.5 | 9.4 | 44.2 | 39 | 22 | 21 | 4 | 17 | 46 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.25 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 28 | 0 | 1 | 0 | 3.73 | .309 | 1.34 | 7.9 | 4.2 | 7.0 | 41.0 | 36 | 17 | 17 | 1 | 19 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.15 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 13 | 1 | 2 | 2 | 6.20 | .344 | 1.52 | 12.2 | 1.8 | 5.0 | 20.1 | 27 | 14 | 14 | 2 | 4 | 11 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.95 |