| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 8 | 8 | 2 | 3 | 4.35 | .284 | 1.19 | 7.9 | 2.9 | 8.6 | 49.2 | 43 | 24 | 24 | 11 | 16 | 47 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 4.98 |
| SP | Hernandez, L.Hernandez, Livan >> | 28 | 2003 | R | 10 | 4 | 4 | 1 | 0 | 3.75 | .321 | 1.38 | 10.5 | 1.9 | 7.9 | 24.0 | 28 | 10 | 10 | 2 | 5 | 21 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 3.08 |
| SP | Webb, B.Webb, Brandon # >> | 24 | 2003 | R | 63 | 8 | 8 | 2 | 2 | 4.94 | .332 | 1.45 | 9.2 | 3.9 | 7.6 | 51.0 | 52 | 28 | 28 | 7 | 22 | 43 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | 4.51 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 8 | 8 | 3 | 3 | 5.66 | .341 | 1.55 | 10.5 | 3.6 | 6.3 | 47.2 | 55 | 31 | 30 | 11 | 19 | 33 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.85 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 42 | 5 | 0 | 1 | 0 | 1.93 | .391 | 1.93 | 11.3 | 9.0 | 22.5 | 4.2 | 5 | 1 | 1 | 1 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.25 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 59 | 14 | 0 | 1 | 1 | 4.50 | .311 | 1.36 | 6.4 | 5.8 | 8.4 | 14.0 | 10 | 7 | 7 | 1 | 9 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.00 |
| SU | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 50 | 16 | 0 | 0 | 0 | 3.12 | .307 | 1.27 | 5.8 | 5.8 | 12.2 | 17.1 | 11 | 6 | 6 | 2 | 11 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.94 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 86 | 9 | 0 | 1 | 0 | 6.30 | .333 | 1.50 | 9.0 | 4.5 | 7.2 | 10.0 | 10 | 7 | 7 | 3 | 5 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.80 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 17 | 0 | 2 | 1 | 6.27 | .341 | 1.55 | 7.0 | 7.5 | 9.5 | 18.2 | 14 | 13 | 13 | 4 | 15 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 6.28 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 14 | 0 | 2 | 3 | 7.30 | .383 | 1.70 | 11.3 | 4.5 | 6.8 | 12.1 | 15 | 10 | 10 | 1 | 6 | 9 | 0 | 6 | 4 | 0 | 0 | 2 | 0 | 4.58 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 7 | 6 | 1 | 3 | 6.37 | .365 | 1.73 | 12.1 | 3.6 | 6.9 | 35.1 | 47 | 28 | 25 | 8 | 14 | 27 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 5.63 |
| CL | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 20 | 0 | 0 | 2 | 2.00 | .277 | 1.15 | 7.7 | 2.7 | 7.0 | 27.0 | 23 | 6 | 6 | 2 | 8 | 21 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.30 |