| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 34 | 34 | 8 | 16 | 3.87 | .297 | 1.25 | 7.9 | 3.3 | 8.7 | 218.1 | 192 | 105 | 94 | 30 | 81 | 210 | 1 | 0 | 0 | 1 | 22 | 4 | 4 | 4.03 |
| SP | Webb, B.Webb, Brandon # >> | 24 | 2003 | R | 64 | 32 | 32 | 11 | 11 | 5.50 | .340 | 1.51 | 9.7 | 3.9 | 8.1 | 196.1 | 212 | 129 | 120 | 39 | 84 | 177 | 2 | 0 | 0 | 0 | 12 | 8 | 11 | 5.19 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 33 | 33 | 10 | 13 | 5.62 | .356 | 1.63 | 11.2 | 3.6 | 6.6 | 185.2 | 230 | 120 | 116 | 34 | 73 | 135 | 0 | 0 | 0 | 0 | 13 | 5 | 0 | 5.19 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 30 | 27 | 8 | 9 | 5.15 | .355 | 1.64 | 10.6 | 4.1 | 7.2 | 159.0 | 188 | 103 | 91 | 33 | 73 | 128 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 5.50 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 44 | 63 | 0 | 7 | 0 | 3.38 | .320 | 1.38 | 8.8 | 3.7 | 10.3 | 77.1 | 75 | 31 | 29 | 11 | 32 | 88 | 0 | 3 | 3 | 0 | 0 | 2 | 1 | 3.90 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 65 | 0 | 9 | 3 | 3.20 | .310 | 1.35 | 7.1 | 5.1 | 10.9 | 70.1 | 55 | 25 | 25 | 7 | 40 | 85 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 3.59 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 47 | 0 | 3 | 1 | 4.14 | .344 | 1.53 | 9.4 | 4.6 | 7.6 | 45.2 | 47 | 23 | 21 | 6 | 23 | 38 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 4.71 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 51 | 59 | 0 | 2 | 2 | 4.24 | .318 | 1.39 | 8.0 | 4.5 | 10.4 | 70.0 | 62 | 34 | 33 | 10 | 35 | 81 | 0 | 1 | 3 | 0 | 0 | 1 | 7 | 4.09 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 42 | 0 | 2 | 4 | 2.78 | .299 | 1.24 | 8.2 | 3.0 | 9.0 | 45.1 | 41 | 15 | 14 | 2 | 15 | 45 | 0 | 6 | 5 | 0 | 0 | 2 | 1 | 2.71 |
| RP | Mantei, M.Mantei, Matt # >> | 30 | 2003 | R | 60 | 38 | 0 | 5 | 1 | 4.73 | .306 | 1.30 | 5.6 | 6.1 | 10.4 | 40.0 | 25 | 21 | 21 | 8 | 27 | 46 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 5.40 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 53 | 15 | 11 | 2 | 5 | 6.42 | .382 | 1.86 | 11.8 | 5.0 | 7.5 | 74.1 | 97 | 55 | 53 | 12 | 41 | 62 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 5.09 |
| CL | Okajima, H.Okajima, Hideki † >> | 32 | 2007 | L | 53 | 67 | 0 | 0 | 7 | 1.99 | .260 | 1.04 | 6.2 | 3.2 | 7.2 | 77.0 | 53 | 18 | 17 | 6 | 27 | 62 | 0 | 33 | 2 | 0 | 0 | 1 | 0 | 3.49 |