| SP | Johnson, R.Johnson, Randy $ >> | 38 | 2001 | L | 97 | 19 | 19 | 6 | 6 | 3.42 | .292 | 1.22 | 8.1 | 2.9 | 8.9 | 126.1 | 114 | 53 | 48 | 16 | 40 | 124 | 1 | 0 | 0 | 0 | 12 | 2 | 2 | 3.68 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 80 | 20 | 20 | 10 | 7 | 4.16 | .268 | 1.07 | 7.5 | 2.2 | 9.4 | 127.2 | 106 | 60 | 59 | 22 | 31 | 132 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 3.98 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 20 | 20 | 7 | 9 | 4.39 | .340 | 1.51 | 10.1 | 3.6 | 8.4 | 108.2 | 121 | 60 | 53 | 12 | 43 | 101 | 2 | 0 | 0 | 1 | 11 | 4 | 1 | 3.88 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 76 | 19 | 19 | 4 | 6 | 5.00 | .334 | 1.44 | 8.8 | 4.2 | 8.1 | 99.0 | 97 | 57 | 55 | 19 | 46 | 89 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 5.27 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 19 | 19 | 9 | 6 | 4.62 | .319 | 1.38 | 9.3 | 3.1 | 6.5 | 111.0 | 115 | 61 | 57 | 18 | 38 | 80 | 2 | 0 | 0 | 1 | 8 | 3 | 5 | 4.77 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 79 | 56 | 0 | 2 | 4 | 5.33 | .331 | 1.39 | 7.8 | 4.7 | 10.0 | 54.0 | 47 | 34 | 32 | 9 | 28 | 60 | 0 | 2 | 4 | 0 | 0 | 5 | 1 | 4.78 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 51 | 47 | 0 | 1 | 3 | 2.61 | .289 | 1.20 | 8.6 | 2.3 | 5.1 | 48.1 | 46 | 14 | 14 | 4 | 12 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.77 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 50 | 35 | 0 | 4 | 1 | 3.34 | .286 | 1.20 | 8.0 | 2.8 | 8.0 | 35.0 | 31 | 16 | 13 | 5 | 11 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.03 |
| RP | Guerrier, M.Guerrier, Matt >> | 31 | 2009 | R | 42 | 28 | 0 | 0 | 1 | 5.19 | .320 | 1.33 | 9.3 | 2.9 | 7.4 | 34.2 | 35 | 23 | 20 | 12 | 11 | 28 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 7.18 |
| SU | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 85 | 32 | 0 | 1 | 1 | 2.84 | .280 | 1.11 | 8.4 | 1.7 | 10.5 | 31.2 | 29 | 12 | 10 | 3 | 6 | 36 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 2.71 |