| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 21 | 21 | 6 | 10 | 5.53 | .318 | 1.36 | 9.1 | 3.2 | 9.0 | 122.0 | 123 | 77 | 75 | 27 | 43 | 122 | 0 | 0 | 0 | 0 | 9 | 5 | 1 | 5.06 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 20 | 20 | 8 | 7 | 4.30 | .295 | 1.22 | 8.4 | 2.7 | 9.6 | 125.2 | 116 | 62 | 60 | 19 | 37 | 133 | 0 | 0 | 0 | 0 | 12 | 5 | 3 | 3.86 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 76 | 19 | 19 | 8 | 5 | 4.35 | .349 | 1.60 | 8.6 | 5.8 | 9.5 | 101.1 | 97 | 49 | 49 | 8 | 65 | 107 | 0 | 0 | 0 | 0 | 10 | 1 | 2 | 3.87 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 19 | 19 | 8 | 8 | 6.88 | .354 | 1.61 | 11.4 | 3.2 | 6.8 | 87.2 | 110 | 67 | 67 | 15 | 31 | 66 | 1 | 0 | 0 | 0 | 6 | 3 | 1 | 4.90 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 54 | 0 | 4 | 0 | 3.00 | .221 | 0.85 | 5.3 | 2.4 | 8.0 | 60.0 | 35 | 21 | 20 | 8 | 16 | 53 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.77 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 56 | 0 | 4 | 2 | 6.67 | .331 | 1.45 | 10.1 | 2.9 | 9.8 | 55.1 | 62 | 42 | 41 | 14 | 18 | 60 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 5.22 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 40 | 0 | 1 | 4 | 4.17 | .310 | 1.32 | 8.8 | 3.2 | 7.8 | 45.1 | 44 | 23 | 21 | 6 | 16 | 39 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 4.13 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 59 | 31 | 0 | 2 | 0 | 3.95 | .317 | 1.35 | 6.7 | 5.7 | 6.0 | 27.1 | 20 | 13 | 12 | 6 | 17 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.56 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 54 | 33 | 0 | 0 | 0 | 4.21 | .252 | 1.01 | 6.5 | 2.9 | 8.3 | 25.2 | 18 | 12 | 12 | 4 | 8 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 50 | 17 | 0 | 1 | 0 | 4.29 | .276 | 1.14 | 9.0 | 1.3 | 6.0 | 21.0 | 21 | 11 | 10 | 5 | 3 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.19 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 49 | 23 | 0 | 0 | 0 | 7.99 | .388 | 1.86 | 12.9 | 4.3 | 6.7 | 23.2 | 33 | 22 | 21 | 4 | 11 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.35 |
| CL | Wagner, B.Wagner, Billy † >> | 33 | 2004 | L | 91 | 40 | 0 | 3 | 3 | 2.50 | .227 | 0.88 | 5.5 | 2.5 | 8.1 | 39.2 | 24 | 16 | 11 | 5 | 11 | 35 | 0 | 26 | 2 | 0 | 0 | 0 | 1 | 3.72 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 88 | 35 | 0 | 1 | 0 | 3.72 | .314 | 1.34 | 9.5 | 2.8 | 9.0 | 38.2 | 40 | 16 | 16 | 6 | 12 | 38 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.08 |