| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 21 | 21 | 9 | 2 | 3.94 | .297 | 1.23 | 7.9 | 3.2 | 6.9 | 114.1 | 100 | 50 | 50 | 13 | 41 | 88 | 1 | 0 | 0 | 1 | 7 | 4 | 6 | 4.12 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 20 | 20 | 4 | 14 | 6.96 | .354 | 1.61 | 10.8 | 3.7 | 7.2 | 94.1 | 113 | 81 | 73 | 28 | 39 | 75 | 1 | 0 | 0 | 0 | 5 | 3 | 2 | 6.62 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 84 | 20 | 20 | 7 | 7 | 4.05 | .292 | 1.23 | 8.3 | 2.8 | 6.5 | 100.0 | 92 | 45 | 45 | 16 | 31 | 72 | 0 | 0 | 0 | 0 | 8 | 1 | 1 | 4.60 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 19 | 19 | 2 | 5 | 6.55 | .376 | 1.79 | 12.5 | 3.7 | 6.5 | 90.2 | 125 | 68 | 66 | 20 | 37 | 65 | 0 | 0 | 0 | 0 | 3 | 2 | 3 | 5.74 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 47 | 0 | 1 | 2 | 5.43 | .321 | 1.40 | 8.2 | 4.4 | 11.2 | 53.0 | 48 | 34 | 32 | 9 | 26 | 66 | 0 | 3 | 4 | 0 | 0 | 1 | 3 | 4.25 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 44 | 0 | 0 | 2 | 4.41 | .293 | 1.22 | 7.9 | 3.1 | 9.7 | 49.0 | 43 | 26 | 24 | 12 | 17 | 53 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 5.12 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 33 | 0 | 3 | 2 | 7.42 | .389 | 1.88 | 10.8 | 6.3 | 6.6 | 30.1 | 36 | 26 | 25 | 8 | 21 | 22 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 7.20 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 56 | 60 | 0 | 3 | 3 | 5.85 | .350 | 1.59 | 10.3 | 4.2 | 8.4 | 47.2 | 54 | 33 | 31 | 11 | 22 | 44 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 5.64 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 43 | 0 | 2 | 5 | 3.73 | .248 | 0.97 | 7.5 | 1.3 | 9.6 | 62.2 | 52 | 27 | 26 | 14 | 9 | 66 | 0 | 12 | 3 | 0 | 0 | 1 | 0 | 4.29 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 11 | 0 | 1 | 1 | 5.19 | .350 | 1.62 | 11.1 | 3.7 | 5.8 | 17.1 | 21 | 10 | 10 | 3 | 7 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.24 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 41 | 0 | 2 | 1 | 3.66 | .272 | 1.12 | 6.7 | 3.5 | 7.4 | 51.2 | 38 | 21 | 21 | 4 | 20 | 42 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.55 |