| SP | Liriano, F.Liriano, Francisco $ >> | 23 | 2006 | L | 98 | 36 | 36 | 6 | 8 | 4.53 | .332 | 1.45 | 9.1 | 3.9 | 9.7 | 149.0 | 151 | 83 | 75 | 19 | 65 | 160 | 0 | 0 | 0 | 0 | 2 | 6 | 14 | 3.94 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 35 | 35 | 9 | 14 | 4.89 | .343 | 1.53 | 10.1 | 3.7 | 7.8 | 189.2 | 212 | 121 | 103 | 35 | 78 | 163 | 1 | 0 | 0 | 1 | 19 | 7 | 1 | 5.03 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 33 | 33 | 4 | 9 | 7.00 | .353 | 1.60 | 11.4 | 3.0 | 7.0 | 127.1 | 161 | 99 | 99 | 27 | 43 | 99 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 5.31 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 33 | 33 | 5 | 13 | 6.39 | .349 | 1.58 | 11.1 | 3.2 | 6.1 | 177.1 | 218 | 136 | 126 | 31 | 63 | 120 | 2 | 0 | 0 | 1 | 10 | 4 | 5 | 5.06 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 31 | 31 | 11 | 8 | 4.90 | .341 | 1.51 | 10.6 | 3.1 | 6.9 | 176.1 | 207 | 112 | 96 | 30 | 60 | 135 | 0 | 0 | 0 | 0 | 16 | 7 | 4 | 4.82 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 66 | 103 | 0 | 12 | 6 | 4.66 | .296 | 1.24 | 8.7 | 2.5 | 7.0 | 129.1 | 124 | 67 | 67 | 24 | 36 | 100 | 0 | 3 | 1 | 0 | 0 | 3 | 3 | 4.78 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 100 | 0 | 7 | 4 | 5.91 | .361 | 1.64 | 10.5 | 4.2 | 6.9 | 102.0 | 119 | 70 | 67 | 16 | 48 | 78 | 0 | 5 | 5 | 0 | 0 | 6 | 3 | 5.10 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 111 | 0 | 7 | 0 | 4.37 | .285 | 1.16 | 7.6 | 2.9 | 9.7 | 101.0 | 85 | 50 | 49 | 18 | 32 | 109 | 0 | 2 | 3 | 0 | 0 | 4 | 6 | 4.23 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 88 | 0 | 7 | 3 | 4.52 | .314 | 1.28 | 7.1 | 4.6 | 8.2 | 65.2 | 51 | 34 | 33 | 10 | 33 | 59 | 0 | 5 | 7 | 0 | 0 | 6 | 0 | 4.98 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 84 | 0 | 3 | 2 | 4.90 | .319 | 1.41 | 7.8 | 4.9 | 9.7 | 75.1 | 65 | 42 | 41 | 13 | 41 | 81 | 0 | 1 | 2 | 0 | 0 | 0 | 5 | 4.73 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 30 | 0 | 6 | 5 | 3.63 | .274 | 1.13 | 7.8 | 2.4 | 6.4 | 52.0 | 45 | 21 | 21 | 9 | 14 | 37 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 4.63 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 96 | 71 | 0 | 6 | 7 | 3.85 | .298 | 1.23 | 7.9 | 3.2 | 9.2 | 107.2 | 94 | 48 | 46 | 10 | 38 | 109 | 0 | 15 | 4 | 0 | 0 | 5 | 0 | 3.38 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 72 | 0 | 5 | 1 | 3.33 | .292 | 1.21 | 5.8 | 5.2 | 8.4 | 78.1 | 50 | 33 | 29 | 10 | 45 | 73 | 0 | 6 | 0 | 0 | 0 | 2 | 2 | 4.60 |