| SP | Martinez, P.Martinez, Pedro † $ >> | 29 | 2000 | R | 100 | 21 | 21 | 11 | 6 | 4.44 | .295 | 1.23 | 8.7 | 2.3 | 9.7 | 142.0 | 138 | 71 | 70 | 24 | 37 | 153 | 3 | 0 | 0 | 1 | 11 | 3 | 1 | 3.89 |
| SP | Carpenter, C.Carpenter, Chris # >> | 34 | 2009 | R | 80 | 20 | 20 | 4 | 9 | 5.26 | .317 | 1.35 | 9.7 | 2.5 | 4.9 | 116.1 | 125 | 69 | 68 | 20 | 32 | 63 | 0 | 0 | 0 | 0 | 8 | 5 | 2 | 5.11 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 20 | 20 | 4 | 3 | 5.33 | .347 | 1.54 | 10.6 | 3.3 | 7.1 | 82.2 | 97 | 52 | 49 | 9 | 30 | 65 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 4.12 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 19 | 19 | 8 | 8 | 4.69 | .319 | 1.39 | 9.2 | 3.3 | 5.6 | 113.1 | 116 | 71 | 59 | 14 | 42 | 70 | 1 | 0 | 0 | 1 | 9 | 1 | 2 | 4.51 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 21 | 19 | 5 | 10 | 6.12 | .338 | 1.50 | 10.1 | 3.5 | 6.3 | 114.2 | 128 | 79 | 78 | 19 | 44 | 80 | 0 | 1 | 0 | 0 | 6 | 4 | 2 | 5.03 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 30 | 0 | 0 | 1 | 2.27 | .240 | 0.95 | 6.4 | 2.3 | 9.0 | 31.2 | 22 | 8 | 8 | 1 | 8 | 31 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 2.19 |
| SU | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 36 | 0 | 1 | 2 | 3.03 | .261 | 1.06 | 7.3 | 2.4 | 9.5 | 38.2 | 31 | 13 | 13 | 4 | 10 | 40 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.05 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 37 | 0 | 6 | 2 | 2.72 | .316 | 1.36 | 7.2 | 5.3 | 8.3 | 39.2 | 31 | 14 | 12 | 1 | 23 | 36 | 0 | 1 | 4 | 0 | 0 | 1 | 4 | 3.33 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 48 | 0 | 6 | 0 | 3.10 | .344 | 1.50 | 9.0 | 4.7 | 7.7 | 40.2 | 40 | 18 | 14 | 3 | 21 | 34 | 0 | 1 | 0 | 0 | 0 | 3 | 4 | 4.08 |
| RP | Remlinger, M.Remlinger, Mike >> | 36 | 2002 | L | 36 | 34 | 0 | 0 | 0 | 3.86 | .339 | 1.46 | 8.4 | 4.8 | 9.3 | 28.0 | 26 | 12 | 12 | 3 | 15 | 29 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.14 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 31 | 0 | 3 | 0 | 4.76 | .342 | 1.53 | 9.5 | 4.2 | 12.4 | 34.0 | 36 | 18 | 18 | 6 | 16 | 47 | 0 | 0 | 4 | 0 | 0 | 1 | 1 | 4.03 |