| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 14 | 14 | 3 | 4 | 4.31 | .288 | 1.19 | 8.5 | 2.2 | 9.4 | 94.0 | 89 | 47 | 45 | 16 | 23 | 98 | 2 | 0 | 0 | 0 | 7 | 2 | 2 | 3.93 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 13 | 13 | 6 | 4 | 4.89 | .322 | 1.40 | 10.8 | 1.9 | 5.6 | 77.1 | 92 | 44 | 42 | 11 | 16 | 48 | 1 | 0 | 0 | 1 | 7 | 2 | 1 | 4.31 |
| SP | Millwood, K.Millwood, Kevin # >> | 28 | 2002 | R | 50 | 13 | 13 | 4 | 4 | 6.06 | .381 | 1.74 | 10.6 | 5.2 | 5.2 | 68.1 | 80 | 53 | 46 | 10 | 39 | 39 | 0 | 0 | 0 | 0 | 3 | 7 | 0 | 5.79 |
| CL | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 25 | 0 | 5 | 5 | 3.26 | .260 | 1.05 | 7.5 | 2.1 | 8.7 | 30.1 | 25 | 11 | 11 | 4 | 7 | 29 | 0 | 10 | 4 | 0 | 0 | 0 | 0 | 3.50 |
| SU | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 31 | 0 | 0 | 0 | 3.24 | .265 | 1.05 | 6.5 | 3.0 | 10.4 | 33.1 | 24 | 12 | 12 | 4 | 11 | 38 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.36 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 28 | 0 | 2 | 3 | 2.93 | .270 | 1.11 | 8.4 | 1.8 | 9.3 | 30.2 | 28 | 13 | 10 | 6 | 6 | 31 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 4.13 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 21 | 0 | 0 | 2 | 2.50 | .239 | 0.94 | 4.0 | 4.5 | 9.5 | 18.0 | 8 | 5 | 5 | 2 | 9 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.83 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 16 | 0 | 2 | 0 | 3.31 | .234 | 0.92 | 5.1 | 3.4 | 9.6 | 16.1 | 9 | 8 | 6 | 2 | 6 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.63 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 32 | 0 | 2 | 0 | 3.79 | .310 | 1.29 | 10.0 | 1.8 | 10.0 | 35.2 | 39 | 17 | 15 | 4 | 7 | 39 | 0 | 2 | 2 | 0 | 0 | 2 | 4 | 3.03 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 54 | 23 | 0 | 1 | 0 | 4.73 | .355 | 1.65 | 10.4 | 4.8 | 9.7 | 13.1 | 15 | 7 | 7 | 0 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.46 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 16 | 0 | 0 | 1 | 4.96 | .347 | 1.53 | 8.4 | 5.6 | 8.4 | 16.1 | 15 | 9 | 9 | 1 | 10 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.00 |