| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 21 | 21 | 8 | 8 | 3.52 | .266 | 1.07 | 7.2 | 2.4 | 9.6 | 148.1 | 119 | 60 | 58 | 18 | 40 | 158 | 2 | 0 | 0 | 1 | 13 | 2 | 2 | 3.30 |
| SP | Vazquez, J.Vazquez, Javier † # >> | 33 | 2009 | R | 87 | 20 | 20 | 10 | 7 | 3.30 | .257 | 1.02 | 7.4 | 1.9 | 10.3 | 141.2 | 116 | 53 | 52 | 15 | 29 | 161 | 6 | 0 | 0 | 2 | 12 | 2 | 1 | 2.76 |
| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 86 | 20 | 20 | 13 | 2 | 3.52 | .288 | 1.19 | 8.8 | 1.9 | 6.0 | 150.2 | 147 | 60 | 59 | 18 | 32 | 100 | 9 | 0 | 0 | 3 | 13 | 4 | 2 | 3.95 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 19 | 19 | 9 | 3 | 5.04 | .362 | 1.70 | 10.2 | 5.1 | 7.0 | 114.1 | 129 | 65 | 64 | 15 | 65 | 89 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 4.89 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 30 | 0 | 3 | 4 | 3.96 | .278 | 1.10 | 8.5 | 1.5 | 10.3 | 36.1 | 34 | 16 | 16 | 5 | 6 | 41 | 0 | 4 | 4 | 0 | 0 | 2 | 2 | 3.19 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 22 | 0 | 0 | 1 | 2.91 | .293 | 1.25 | 10.3 | 1.3 | 11.1 | 21.2 | 24 | 7 | 7 | 3 | 3 | 26 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.81 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 3 | 0 | 1 | 0 | 3.72 | .293 | 1.14 | 7.0 | 4.0 | 8.0 | 9.2 | 7 | 4 | 4 | 1 | 4 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.33 |