| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 18 | 18 | 8 | 8 | 3.49 | .300 | 1.27 | 8.7 | 2.8 | 9.8 | 134.0 | 129 | 63 | 52 | 18 | 41 | 146 | 3 | 0 | 0 | 2 | 10 | 2 | 3 | 3.53 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 17 | 17 | 0 | 3 | 5.06 | .347 | 1.52 | 9.8 | 3.8 | 6.3 | 64.0 | 70 | 37 | 36 | 4 | 27 | 45 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 3.91 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 68 | 17 | 17 | 5 | 7 | 4.53 | .296 | 1.25 | 8.9 | 2.4 | 6.3 | 113.1 | 112 | 63 | 57 | 20 | 30 | 79 | 3 | 0 | 0 | 1 | 9 | 1 | 0 | 4.73 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 17 | 17 | 7 | 5 | 5.12 | .334 | 1.49 | 10.2 | 3.2 | 7.6 | 109.0 | 123 | 62 | 62 | 20 | 39 | 92 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 4.83 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 43 | 0 | 1 | 3 | 5.31 | .310 | 1.35 | 8.8 | 3.4 | 6.4 | 59.1 | 58 | 36 | 35 | 8 | 22 | 42 | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 4.46 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 40 | 0 | 5 | 4 | 4.92 | .271 | 1.08 | 5.9 | 3.7 | 4.2 | 53.0 | 35 | 29 | 29 | 12 | 22 | 25 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 6.36 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 38 | 28 | 0 | 2 | 2 | 4.17 | .290 | 1.20 | 9.3 | 1.8 | 6.8 | 36.2 | 37 | 18 | 17 | 5 | 7 | 27 | 0 | 2 | 1 | 0 | 0 | 1 | 4 | 3.97 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 5 | 1 | 0 | 1 | 9.00 | .429 | 2.25 | 13.5 | 6.8 | 9.0 | 8.0 | 12 | 9 | 8 | 2 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.50 |
| SP | Miller, W.Miller, Wade >> | 25 | 2001 | R | 28 | 16 | 0 | 1 | 5 | 6.69 | .366 | 1.73 | 10.3 | 5.5 | 7.0 | 36.1 | 41 | 31 | 27 | 7 | 22 | 28 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 5.81 |