| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 8 | 8 | 3 | 3 | 4.50 | .297 | 1.25 | 8.8 | 2.4 | 8.1 | 52.0 | 51 | 27 | 26 | 9 | 14 | 47 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 4.31 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 8 | 8 | 1 | 2 | 3.96 | .327 | 1.35 | 9.5 | 2.8 | 6.0 | 36.1 | 38 | 16 | 16 | 1 | 11 | 24 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 3.28 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 8 | 8 | 4 | 2 | 3.74 | .346 | 1.57 | 10.2 | 3.9 | 5.1 | 53.0 | 60 | 22 | 22 | 4 | 23 | 30 | 1 | 0 | 0 | 0 | 5 | 1 | 0 | 4.21 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 7 | 7 | 3 | 2 | 3.80 | .297 | 1.24 | 8.4 | 2.8 | 9.4 | 45.0 | 42 | 20 | 19 | 4 | 14 | 47 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 3.07 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 21 | 0 | 3 | 0 | 4.23 | .336 | 1.52 | 8.3 | 5.7 | 9.7 | 27.2 | 25 | 13 | 13 | 2 | 17 | 29 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.70 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 20 | 0 | 1 | 3 | 9.43 | .388 | 1.90 | 16.3 | 0.9 | 9.0 | 21.0 | 38 | 22 | 22 | 3 | 2 | 21 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 3.14 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 44 | 11 | 0 | 0 | 1 | 6.39 | .321 | 1.34 | 8.3 | 4.5 | 9.0 | 12.2 | 11 | 9 | 9 | 2 | 6 | 12 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.92 |
| CL | Gagne, E.Gagne, Eric $$ >> | 27 | 2003 | R | 100 | 18 | 0 | 2 | 0 | 2.45 | .236 | 0.87 | 5.5 | 2.5 | 12.0 | 18.1 | 11 | 5 | 5 | 4 | 5 | 24 | 0 | 9 | 0 | 0 | 0 | 1 | 0 | 4.22 |