| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 34 | 34 | 19 | 8 | 3.06 | .273 | 1.11 | 8.1 | 1.9 | 10.2 | 238.0 | 214 | 82 | 81 | 24 | 51 | 270 | 1 | 0 | 0 | 1 | 23 | 3 | 2 | 2.72 |
| SP | Lodolo, N.Lodolo, Nick >> | 27 | 2025 | L | 78 | 34 | 34 | 10 | 9 | 4.31 | .323 | 1.40 | 9.5 | 3.0 | 9.4 | 192.0 | 203 | 93 | 92 | 30 | 65 | 200 | 0 | 0 | 0 | 0 | 11 | 7 | 3 | 4.07 |
| SP | Mahle, T.Mahle, Tyler # >> | 30 | 2025 | R | 73 | 33 | 33 | 15 | 8 | 4.32 | .306 | 1.26 | 8.9 | 2.5 | 6.9 | 191.2 | 189 | 94 | 92 | 33 | 53 | 147 | 0 | 0 | 0 | 0 | 16 | 11 | 0 | 4.71 |
| SP | Burrows, M.Burrows, Mike # >> | 25 | 2025 | R | 62 | 33 | 33 | 8 | 7 | 5.33 | .318 | 1.39 | 10.0 | 2.5 | 10.7 | 147.0 | 164 | 91 | 87 | 24 | 41 | 174 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 3.61 |
| SP | Priester, Q.Priester, Quinn >> | 24 | 2025 | R | 53 | 30 | 30 | 6 | 13 | 4.92 | .335 | 1.47 | 9.7 | 3.6 | 8.1 | 166.1 | 179 | 99 | 91 | 32 | 66 | 149 | 0 | 0 | 0 | 0 | 7 | 6 | 8 | 5.01 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 86 | 89 | 0 | 7 | 5 | 3.63 | .296 | 1.26 | 8.3 | 3.0 | 8.4 | 121.1 | 112 | 51 | 49 | 17 | 41 | 113 | 0 | 7 | 5 | 0 | 0 | 0 | 4 | 3.98 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 72 | 79 | 0 | 5 | 6 | 4.76 | .322 | 1.37 | 7.8 | 4.6 | 9.2 | 96.1 | 83 | 53 | 51 | 12 | 49 | 98 | 0 | 10 | 5 | 0 | 0 | 5 | 5 | 4.27 |
| RP | Hoffman, J.Hoffman, Jeff >> | 32 | 2025 | R | 61 | 67 | 0 | 5 | 9 | 3.76 | .318 | 1.32 | 7.8 | 4.1 | 10.5 | 76.2 | 66 | 32 | 32 | 7 | 35 | 89 | 0 | 9 | 4 | 0 | 0 | 6 | 0 | 3.47 |
| RP | Herget, J.Herget, Jimmy >> | 31 | 2025 | R | 55 | 67 | 0 | 2 | 4 | 4.87 | .323 | 1.42 | 10.2 | 2.7 | 8.2 | 77.2 | 87 | 42 | 42 | 13 | 23 | 70 | 0 | 8 | 6 | 0 | 0 | 1 | 3 | 4.31 |