| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 6 | 6 | 5 | 1 | 2.28 | .222 | 0.83 | 5.7 | 1.9 | 11.1 | 43.1 | 27 | 11 | 11 | 3 | 9 | 53 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 2.14 |
| SP | Lodolo, N.Lodolo, Nick >> | 27 | 2025 | L | 78 | 6 | 6 | 2 | 1 | 4.41 | .359 | 1.65 | 12.1 | 3.1 | 8.7 | 32.2 | 43 | 16 | 16 | 3 | 11 | 31 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 3.41 |
| SP | Mahle, T.Mahle, Tyler # >> | 30 | 2025 | R | 73 | 6 | 6 | 4 | 1 | 5.56 | .311 | 1.29 | 9.0 | 2.6 | 6.9 | 34.0 | 34 | 21 | 21 | 6 | 10 | 26 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 4.82 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 62 | 6 | 6 | 0 | 1 | 8.88 | .354 | 1.64 | 13.9 | 1.1 | 10.9 | 24.1 | 37 | 24 | 24 | 7 | 3 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.75 |
| SP | Priester, Q.Priester, Quinn >> | 24 | 2025 | R | 53 | 5 | 5 | 1 | 2 | 8.03 | .403 | 1.95 | 13.5 | 4.5 | 8.3 | 24.2 | 36 | 29 | 22 | 10 | 12 | 22 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 8.33 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 86 | 17 | 0 | 2 | 2 | 2.16 | .202 | 0.76 | 5.8 | 1.1 | 7.9 | 25.0 | 16 | 6 | 6 | 2 | 3 | 22 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.64 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 72 | 15 | 0 | 0 | 1 | 1.64 | .224 | 0.82 | 4.5 | 2.9 | 7.0 | 22.0 | 11 | 4 | 4 | 1 | 7 | 17 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.14 |
| RP | Hoffman, J.Hoffman, Jeff >> | 32 | 2025 | R | 61 | 12 | 0 | 0 | 1 | 3.38 | .322 | 1.35 | 9.7 | 2.8 | 12.5 | 13.1 | 14 | 5 | 5 | 1 | 4 | 18 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.38 |
| RP | Herget, J.Herget, Jimmy >> | 31 | 2025 | R | 55 | 9 | 0 | 0 | 0 | 1.93 | .222 | 0.86 | 6.0 | 2.0 | 13.0 | 9.1 | 6 | 2 | 2 | 0 | 2 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0.78 |