| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 25 | 25 | 4 | 14 | 4.19 | .294 | 1.24 | 8.7 | 2.4 | 11.3 | 159.0 | 154 | 82 | 74 | 24 | 43 | 199 | 3 | 0 | 0 | 0 | 14 | 2 | 3 | 3.31 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 89 | 24 | 24 | 6 | 3 | 4.35 | .331 | 1.45 | 7.8 | 5.3 | 11.6 | 120.0 | 104 | 60 | 58 | 13 | 70 | 154 | 0 | 0 | 0 | 0 | 5 | 4 | 3 | 3.69 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 81 | 24 | 24 | 5 | 12 | 7.00 | .369 | 1.75 | 11.5 | 4.4 | 6.5 | 124.2 | 158 | 107 | 97 | 26 | 60 | 90 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 5.75 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 67 | 25 | 23 | 7 | 10 | 5.82 | .343 | 1.53 | 10.8 | 3.0 | 8.3 | 133.0 | 159 | 89 | 86 | 25 | 45 | 123 | 0 | 1 | 0 | 0 | 8 | 4 | 1 | 4.70 |
| CL | Miller, M.Miller, Mason # >> | 26 | 2025 | R | 99 | 66 | 0 | 5 | 9 | 5.07 | .345 | 1.56 | 6.6 | 7.5 | 12.0 | 71.0 | 52 | 44 | 40 | 9 | 59 | 95 | 0 | 11 | 4 | 0 | 0 | 1 | 10 | 4.51 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 90 | 68 | 0 | 5 | 3 | 3.13 | .297 | 1.26 | 7.9 | 3.4 | 9.7 | 89.0 | 78 | 37 | 31 | 9 | 34 | 96 | 0 | 2 | 4 | 0 | 0 | 1 | 3 | 3.34 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 79 | 76 | 0 | 6 | 1 | 2.76 | .277 | 1.14 | 7.7 | 2.7 | 10.1 | 94.2 | 80 | 32 | 29 | 8 | 28 | 105 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 2.80 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 65 | 0 | 3 | 3 | 4.36 | .298 | 1.26 | 6.8 | 4.6 | 10.9 | 76.1 | 57 | 37 | 37 | 7 | 39 | 92 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 3.36 |
| RP | Estrada, J.Estrada, Jeremiah $ >> | 26 | 2025 | R | 67 | 59 | 0 | 4 | 3 | 4.22 | .326 | 1.42 | 9.0 | 3.8 | 11.0 | 64.0 | 64 | 34 | 30 | 9 | 27 | 78 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 3.75 |