| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 24 | 24 | 8 | 8 | 3.28 | .252 | 0.98 | 7.0 | 1.8 | 8.6 | 161.2 | 126 | 60 | 59 | 20 | 32 | 153 | 1 | 0 | 0 | 0 | 18 | 5 | 0 | 3.40 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 24 | 24 | 8 | 12 | 3.30 | .242 | 0.93 | 7.1 | 1.4 | 5.3 | 171.2 | 134 | 66 | 63 | 22 | 26 | 101 | 9 | 0 | 0 | 1 | 16 | 4 | 1 | 4.02 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 23 | 23 | 8 | 9 | 3.70 | .292 | 1.23 | 8.1 | 2.9 | 8.0 | 151.0 | 136 | 63 | 62 | 19 | 49 | 134 | 0 | 0 | 0 | 0 | 15 | 2 | 2 | 3.87 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 23 | 23 | 4 | 7 | 4.32 | .323 | 1.39 | 8.4 | 4.0 | 7.6 | 98.0 | 92 | 50 | 47 | 11 | 44 | 83 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 4.23 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 24 | 22 | 7 | 13 | 4.11 | .280 | 1.15 | 7.2 | 3.1 | 6.0 | 151.0 | 121 | 77 | 69 | 21 | 52 | 101 | 5 | 0 | 0 | 1 | 11 | 3 | 3 | 4.56 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 63 | 0 | 4 | 2 | 1.94 | .197 | 0.71 | 5.7 | 0.8 | 7.8 | 78.2 | 49 | 20 | 17 | 10 | 7 | 68 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.27 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 57 | 0 | 0 | 5 | 3.35 | .297 | 1.27 | 7.1 | 4.4 | 5.9 | 53.2 | 42 | 22 | 20 | 10 | 26 | 35 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 5.60 |
| CL | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 43 | 0 | 2 | 4 | 1.92 | .293 | 1.22 | 7.1 | 4.0 | 9.2 | 56.1 | 44 | 13 | 12 | 4 | 25 | 57 | 0 | 25 | 4 | 0 | 0 | 1 | 0 | 3.29 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 40 | 0 | 3 | 2 | 3.94 | .250 | 1.00 | 7.3 | 1.7 | 6.2 | 32.0 | 26 | 15 | 14 | 8 | 6 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.44 |