| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 21 | 21 | 7 | 3 | 3.46 | .309 | 1.32 | 7.5 | 4.4 | 8.0 | 122.1 | 101 | 53 | 47 | 13 | 60 | 108 | 0 | 0 | 0 | 0 | 11 | 3 | 2 | 4.16 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 20 | 20 | 6 | 5 | 3.79 | .276 | 1.13 | 8.9 | 1.3 | 4.8 | 133.0 | 131 | 57 | 56 | 8 | 19 | 71 | 3 | 0 | 0 | 3 | 11 | 2 | 1 | 3.19 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 19 | 19 | 6 | 5 | 4.14 | .294 | 1.23 | 7.8 | 3.4 | 7.8 | 108.2 | 93 | 51 | 50 | 12 | 41 | 93 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 3.92 |
| SP | McDowell, S.McDowell, Sam † >> | 23 | 1965 | L | 44 | 19 | 19 | 10 | 5 | 3.30 | .296 | 1.22 | 6.9 | 4.1 | 7.8 | 122.2 | 94 | 51 | 45 | 12 | 56 | 106 | 0 | 0 | 0 | 0 | 15 | 5 | 4 | 4.04 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 19 | 19 | 5 | 8 | 4.49 | .311 | 1.34 | 9.4 | 2.8 | 5.0 | 124.1 | 129 | 74 | 62 | 14 | 38 | 69 | 2 | 0 | 0 | 0 | 9 | 1 | 2 | 4.30 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 57 | 0 | 5 | 2 | 4.29 | .357 | 1.63 | 7.4 | 7.3 | 8.4 | 63.0 | 52 | 32 | 30 | 7 | 51 | 59 | 0 | 0 | 6 | 0 | 0 | 2 | 7 | 5.10 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 50 | 0 | 3 | 1 | 4.30 | .308 | 1.34 | 7.7 | 4.5 | 8.7 | 60.2 | 51 | 29 | 29 | 10 | 30 | 58 | 0 | 1 | 3 | 0 | 0 | 0 | 4 | 4.73 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 41 | 0 | 7 | 3 | 2.00 | .243 | 0.94 | 5.8 | 2.7 | 9.8 | 54.0 | 35 | 12 | 12 | 2 | 16 | 59 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2.24 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 37 | 0 | 4 | 3 | 2.13 | .278 | 1.14 | 4.7 | 5.6 | 5.6 | 63.1 | 33 | 20 | 15 | 4 | 39 | 39 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 4.49 |
| CL | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 74 | 47 | 0 | 3 | 7 | 3.46 | .294 | 1.25 | 6.6 | 4.7 | 8.7 | 52.0 | 38 | 23 | 20 | 8 | 27 | 50 | 0 | 20 | 2 | 0 | 0 | 0 | 1 | 4.63 |