| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 35 | 35 | 19 | 12 | 3.85 | .290 | 1.21 | 7.2 | 3.6 | 4.7 | 222.1 | 178 | 98 | 95 | 19 | 90 | 116 | 1 | 0 | 0 | 1 | 21 | 4 | 3 | 4.34 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 33 | 33 | 17 | 9 | 3.12 | .268 | 1.07 | 7.8 | 1.8 | 5.2 | 225.1 | 196 | 81 | 78 | 13 | 46 | 130 | 8 | 0 | 0 | 4 | 21 | 6 | 3 | 3.29 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 77 | 32 | 32 | 18 | 7 | 2.85 | .263 | 1.06 | 7.1 | 2.4 | 5.9 | 237.0 | 187 | 80 | 75 | 11 | 64 | 156 | 5 | 0 | 0 | 3 | 22 | 3 | 2 | 3.14 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 32 | 32 | 11 | 5 | 4.24 | .321 | 1.41 | 8.1 | 4.6 | 8.4 | 169.2 | 153 | 81 | 80 | 19 | 86 | 157 | 0 | 0 | 0 | 0 | 15 | 2 | 3 | 4.17 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 73 | 0 | 2 | 4 | 3.46 | .307 | 1.30 | 6.5 | 5.1 | 8.0 | 91.0 | 66 | 35 | 35 | 8 | 52 | 81 | 0 | 9 | 4 | 0 | 0 | 3 | 5 | 4.18 |
| RP | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 71 | 65 | 0 | 6 | 3 | 3.19 | .269 | 1.10 | 5.7 | 4.2 | 7.9 | 79.0 | 50 | 29 | 28 | 4 | 37 | 69 | 0 | 10 | 1 | 0 | 0 | 0 | 6 | 3.32 |
| RP | Holland, G.Holland, Greg # >> | 27 | 2013 | R | 71 | 43 | 0 | 3 | 4 | 4.04 | .286 | 1.17 | 8.3 | 2.3 | 11.3 | 55.2 | 51 | 27 | 25 | 9 | 14 | 69 | 0 | 5 | 2 | 0 | 0 | 2 | 1 | 3.49 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 96 | 0 | 8 | 5 | 4.45 | .299 | 1.28 | 9.1 | 2.5 | 7.8 | 121.1 | 122 | 61 | 60 | 9 | 33 | 105 | 0 | 14 | 3 | 0 | 0 | 0 | 0 | 3.05 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 35 | 31 | 15 | 9 | 3.67 | .310 | 1.32 | 8.6 | 3.3 | 4.6 | 215.2 | 205 | 94 | 88 | 21 | 79 | 111 | 4 | 0 | 0 | 1 | 18 | 7 | 5 | 4.44 |