| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 24 | 24 | 9 | 6 | 3.81 | .284 | 1.17 | 7.5 | 3.0 | 5.2 | 127.2 | 106 | 58 | 54 | 12 | 43 | 73 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 4.17 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 23 | 23 | 5 | 7 | 3.86 | .320 | 1.38 | 7.6 | 4.9 | 4.5 | 128.1 | 108 | 60 | 55 | 14 | 69 | 64 | 0 | 0 | 0 | 0 | 11 | 4 | 1 | 5.13 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 23 | 23 | 8 | 4 | 4.44 | .321 | 1.40 | 8.1 | 4.5 | 8.2 | 119.2 | 107 | 60 | 59 | 9 | 60 | 109 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 3.74 |
| RP | Balfour, G.Balfour, Grant # >> | 31 | 2008 | R | 76 | 76 | 0 | 3 | 1 | 2.90 | .273 | 1.11 | 6.0 | 4.1 | 8.7 | 62.0 | 41 | 22 | 20 | 9 | 28 | 60 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 4.35 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 67 | 0 | 2 | 2 | 3.69 | .309 | 1.32 | 7.3 | 4.8 | 8.3 | 53.2 | 43 | 24 | 22 | 2 | 28 | 49 | 0 | 2 | 2 | 0 | 0 | 1 | 9 | 3.28 |
| RP | Urbina, U.Urbina, Ugueth † >> | 24 | 1998 | R | 59 | 52 | 0 | 7 | 1 | 2.32 | .234 | 0.89 | 4.7 | 3.4 | 10.7 | 42.2 | 22 | 11 | 11 | 3 | 16 | 50 | 0 | 8 | 2 | 0 | 0 | 1 | 2 | 2.76 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 33 | 49 | 0 | 0 | 3 | 2.36 | .300 | 1.24 | 6.0 | 5.1 | 7.5 | 42.0 | 28 | 13 | 11 | 4 | 24 | 35 | 0 | 12 | 3 | 0 | 0 | 2 | 0 | 4.43 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 34 | 0 | 5 | 1 | 1.30 | .225 | 0.85 | 5.1 | 2.6 | 5.3 | 48.1 | 27 | 10 | 7 | 1 | 14 | 28 | 0 | 6 | 1 | 0 | 0 | 1 | 2 | 3.04 |