| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 95 | 36 | 36 | 18 | 14 | 4.14 | .314 | 1.34 | 8.1 | 4.0 | 8.2 | 243.2 | 219 | 115 | 112 | 28 | 108 | 222 | 3 | 0 | 0 | 1 | 21 | 7 | 7 | 4.09 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 35 | 35 | 12 | 16 | 4.26 | .314 | 1.34 | 9.1 | 3.0 | 7.9 | 245.1 | 248 | 127 | 116 | 22 | 81 | 216 | 4 | 0 | 0 | 1 | 20 | 8 | 1 | 3.49 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 34 | 34 | 12 | 15 | 4.85 | .318 | 1.38 | 9.1 | 3.3 | 5.0 | 243.1 | 247 | 143 | 131 | 27 | 89 | 135 | 12 | 0 | 0 | 1 | 14 | 5 | 3 | 4.49 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 84 | 0 | 5 | 5 | 3.78 | .282 | 1.15 | 6.9 | 3.5 | 8.3 | 109.2 | 84 | 51 | 46 | 15 | 42 | 101 | 0 | 11 | 2 | 0 | 0 | 3 | 3 | 4.17 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 40 | 0 | 3 | 3 | 6.70 | .351 | 1.58 | 10.2 | 4.2 | 8.2 | 45.2 | 51 | 36 | 34 | 11 | 21 | 41 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 5.89 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 27 | 0 | 5 | 2 | 2.65 | .300 | 1.29 | 7.8 | 3.9 | 5.4 | 37.1 | 32 | 13 | 11 | 4 | 16 | 22 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.51 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 24 | 0 | 0 | 0 | 7.39 | .349 | 1.57 | 11.3 | 2.9 | 8.7 | 28.0 | 35 | 23 | 23 | 7 | 9 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.39 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | - | - | - | 0.2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |