| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 100 | 25 | 25 | 10 | 10 | 3.34 | .292 | 1.20 | 7.3 | 3.5 | 10.5 | 161.2 | 131 | 61 | 60 | 15 | 63 | 187 | 3 | 0 | 0 | 1 | 16 | 6 | 3 | 3.17 |
| SP | Zambrano, C.Zambrano, Carlos >> | 23 | 2004 | R | 50 | 24 | 24 | 4 | 9 | 4.35 | .346 | 1.56 | 8.8 | 5.3 | 7.2 | 140.2 | 137 | 75 | 68 | 13 | 82 | 112 | 2 | 0 | 0 | 0 | 14 | 4 | 4 | 4.45 |
| SP | Hendricks, K.Hendricks, Kyle >> | 28 | 2018 | R | 48 | 23 | 23 | 5 | 8 | 5.37 | .355 | 1.64 | 11.4 | 3.4 | 6.3 | 129.0 | 163 | 84 | 77 | 24 | 49 | 91 | 0 | 0 | 0 | 0 | 10 | 1 | 0 | 5.17 |
| SP | Sutcliffe, R.Sutcliffe, Rick # >> | 28 | 1984 | R | 32 | 23 | 23 | 6 | 9 | 5.52 | .338 | 1.48 | 9.9 | 3.4 | 7.8 | 124.0 | 136 | 79 | 76 | 15 | 47 | 108 | 1 | 0 | 0 | 1 | 9 | 7 | 2 | 4.14 |
| RP | Rondon, H.Rondon, Hector >> | 27 | 2015 | R | 72 | 66 | 0 | 7 | 5 | 4.11 | .336 | 1.44 | 8.5 | 4.5 | 8.3 | 72.1 | 68 | 34 | 33 | 9 | 36 | 66 | 0 | 5 | 2 | 0 | 0 | 6 | 4 | 4.54 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 32 | 2004 | R | 59 | 53 | 0 | 1 | 2 | 3.00 | .293 | 1.25 | 8.1 | 3.2 | 7.7 | 57.0 | 51 | 22 | 19 | 6 | 20 | 49 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3.70 |
| RP | Edwards, C.Edwards, Carl >> | 26 | 2018 | R | 54 | 39 | 0 | 1 | 4 | 4.04 | .389 | 1.88 | 9.5 | 7.7 | 9.8 | 35.2 | 37 | 21 | 16 | 4 | 30 | 38 | 0 | 4 | 1 | 0 | 0 | 1 | 4 | 4.97 |
| RP | Mercker, K.Mercker, Kent >> | 36 | 2004 | L | 53 | 85 | 0 | 0 | 1 | 5.74 | .371 | 1.72 | 10.0 | 5.6 | 7.3 | 47.0 | 52 | 32 | 30 | 12 | 29 | 38 | 0 | 3 | 3 | 0 | 0 | 2 | 1 | 6.68 |