| SP | Cortes Jr., N.Cortes Jr., Nestor # >> | 27 | 2022 | L | 96 | 24 | 24 | 10 | 9 | 4.81 | .298 | 1.21 | 7.9 | 2.9 | 9.2 | 144.0 | 127 | 80 | 77 | 15 | 47 | 147 | 0 | 0 | 0 | 0 | 12 | 9 | 4 | 3.48 |
| SP | Rodon, C.Rodon, Carlos >> | 32 | 2025 | L | 93 | 24 | 24 | 7 | 6 | 3.38 | .299 | 1.27 | 7.1 | 4.3 | 10.0 | 149.0 | 117 | 60 | 56 | 16 | 72 | 166 | 1 | 0 | 0 | 1 | 13 | 2 | 3 | 3.66 |
| SP | Mussina, M.Mussina, Mike >> | 40 | 2008 | R | 31 | 21 | 21 | 11 | 3 | 4.41 | .321 | 1.37 | 9.8 | 2.7 | 6.8 | 132.2 | 143 | 66 | 65 | 14 | 39 | 100 | 0 | 0 | 0 | 0 | 11 | 6 | 0 | 3.89 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 97 | 48 | 0 | 6 | 6 | 1.98 | .261 | 1.00 | 6.7 | 2.3 | 9.4 | 50.0 | 37 | 15 | 11 | 2 | 13 | 52 | 0 | 30 | 4 | 0 | 0 | 3 | 0 | 2.40 |
| RP | Holmes, C.Holmes, Clay >> | 29 | 2022 | R | 76 | 63 | 0 | 4 | 3 | 4.12 | .330 | 1.45 | 8.3 | 4.8 | 9.8 | 78.2 | 72 | 37 | 36 | 13 | 42 | 85 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 4.68 |
| RP | Williams, D.Williams, Devin >> | 30 | 2025 | R | 68 | 60 | 0 | 6 | 1 | 4.08 | .341 | 1.51 | 9.3 | 4.4 | 9.9 | 68.1 | 70 | 31 | 31 | 5 | 33 | 75 | 0 | 1 | 2 | 0 | 0 | 3 | 5 | 3.34 |
| RP | Fisher, B.Fisher, Brian >> | 23 | 1985 | R | 60 | 47 | 0 | 4 | 2 | 4.06 | .293 | 1.19 | 8.6 | 2.2 | 6.1 | 62.0 | 59 | 30 | 28 | 7 | 15 | 42 | 0 | 2 | 2 | 0 | 0 | 3 | 3 | 3.98 |
| RP | Chapman, A.Chapman, Aroldis >> | 34 | 2022 | L | 47 | 25 | 0 | 3 | 1 | 2.86 | .325 | 1.45 | 7.1 | 6.1 | 11.3 | 28.1 | 22 | 10 | 9 | 2 | 19 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.46 |
| RP | Righetti, D.Righetti, Dave >> | 27 | 1985 | L | 36 | 27 | 0 | 2 | 0 | 4.35 | .326 | 1.42 | 7.8 | 4.9 | 6.1 | 31.0 | 27 | 15 | 15 | 4 | 17 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5.06 |
| SP | Warren, W.Warren, Will >> | 26 | 2025 | R | 28 | 9 | 1 | 1 | 3 | 3.41 | .275 | 1.10 | 7.8 | 2.2 | 8.1 | 29.0 | 25 | 11 | 11 | 2 | 7 | 26 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.93 |