| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 35 | 35 | 17 | 6 | 2.95 | .264 | 1.06 | 7.3 | 2.2 | 9.3 | 259.1 | 210 | 90 | 85 | 25 | 64 | 267 | 11 | 0 | 0 | 2 | 22 | 5 | 4 | 2.99 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 67 | 37 | 16 | 9 | 5 | 5.38 | .343 | 1.55 | 10.7 | 3.3 | 7.7 | 147.1 | 175 | 92 | 88 | 22 | 54 | 126 | 0 | 3 | 0 | 0 | 2 | 2 | 11 | 4.37 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 33 | 33 | 15 | 8 | 4.75 | .321 | 1.40 | 9.9 | 2.7 | 4.8 | 187.2 | 206 | 106 | 99 | 21 | 56 | 100 | 4 | 0 | 0 | 0 | 14 | 4 | 4 | 4.35 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 32 | 26 | 9 | 4 | 5.45 | .354 | 1.62 | 11.1 | 3.5 | 9.6 | 140.1 | 172 | 88 | 85 | 21 | 55 | 149 | 0 | 0 | 0 | 0 | 8 | 4 | 2 | 4.09 |
| SP | Loaiza, E.Loaiza, Esteban † >> | 32 | 2003 | R | 60 | 32 | 31 | 14 | 6 | 5.54 | .346 | 1.56 | 10.3 | 3.7 | 7.1 | 164.0 | 188 | 102 | 101 | 20 | 68 | 129 | 1 | 0 | 0 | 0 | 9 | 4 | 2 | 4.33 |
| CL | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 83 | 0 | 4 | 3 | 3.24 | .257 | 1.00 | 6.4 | 2.6 | 8.6 | 94.1 | 67 | 34 | 34 | 12 | 27 | 90 | 0 | 11 | 5 | 0 | 0 | 4 | 0 | 3.73 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 83 | 0 | 6 | 3 | 3.97 | .309 | 1.29 | 7.5 | 4.3 | 11.2 | 65.2 | 54 | 29 | 29 | 9 | 31 | 81 | 0 | 5 | 5 | 0 | 0 | 3 | 6 | 3.88 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 82 | 0 | 6 | 3 | 4.31 | .310 | 1.35 | 8.2 | 4.1 | 5.9 | 64.2 | 58 | 33 | 31 | 7 | 29 | 42 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 4.47 |
| RP | Saito, T.Saito, Takashi # >> | 37 | 2007 | R | 100 | 84 | 0 | 6 | 7 | 4.89 | .281 | 1.12 | 8.1 | 2.0 | 10.0 | 81.0 | 73 | 44 | 44 | 13 | 18 | 90 | 0 | 13 | 5 | 0 | 0 | 4 | 0 | 3.68 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 79 | 0 | 5 | 5 | 3.59 | .325 | 1.42 | 10.4 | 2.5 | 10.3 | 72.2 | 83 | 32 | 29 | 5 | 20 | 82 | 0 | 5 | 2 | 0 | 0 | 2 | 1 | 2.54 |
| RP | Okajima, H.Okajima, Hideki # >> | 32 | 2007 | L | 53 | 58 | 0 | 5 | 5 | 5.19 | .333 | 1.48 | 9.9 | 3.6 | 6.9 | 60.2 | 66 | 35 | 35 | 10 | 24 | 46 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.88 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 36 | 24 | 6 | 8 | 5.98 | .353 | 1.62 | 10.3 | 4.2 | 8.0 | 149.0 | 171 | 100 | 99 | 28 | 70 | 132 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 5.14 |