| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 8 | 8 | 3 | 1 | 1.82 | .231 | 0.90 | 5.9 | 2.3 | 8.3 | 64.1 | 42 | 14 | 13 | 4 | 16 | 59 | 3 | 0 | 0 | 1 | 7 | 0 | 0 | 2.72 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 7 | 7 | 3 | 2 | 4.30 | .320 | 1.41 | 9.6 | 3.1 | 4.1 | 44.0 | 47 | 21 | 21 | 3 | 15 | 20 | 1 | 0 | 0 | 0 | 4 | 0 | 1 | 4.00 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 7 | 1 | 1 | 0 | 3.91 | .330 | 1.43 | 9.4 | 3.5 | 9.0 | 23.0 | 24 | 10 | 10 | 3 | 9 | 23 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.00 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 60 | 8 | 7 | 6 | 0 | 4.24 | .296 | 1.26 | 9.2 | 2.3 | 7.2 | 46.2 | 47 | 22 | 22 | 4 | 12 | 37 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 3.30 |
| CL | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 18 | 0 | 2 | 3 | 4.91 | .323 | 1.43 | 10.9 | 2.6 | 11.6 | 14.2 | 17 | 8 | 8 | 3 | 4 | 18 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 4.07 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 21 | 0 | 2 | 1 | 3.07 | .313 | 1.30 | 7.7 | 4.5 | 9.6 | 14.2 | 12 | 5 | 5 | 2 | 7 | 15 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.43 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 19 | 0 | 1 | 1 | 3.79 | .250 | 0.95 | 6.6 | 1.9 | 10.9 | 19.0 | 14 | 8 | 8 | 2 | 4 | 23 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.74 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 14 | 0 | 0 | 0 | 2.31 | .300 | 1.29 | 8.2 | 4.1 | 5.7 | 11.2 | 10 | 3 | 3 | 0 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.09 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 16 | 0 | 0 | 1 | 6.00 | .368 | 1.75 | 12.8 | 3.0 | 8.3 | 12.0 | 17 | 8 | 8 | 0 | 4 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.17 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 10 | 0 | 2 | 1 | 8.18 | .400 | 2.00 | 12.3 | 5.7 | 4.9 | 11.0 | 15 | 10 | 10 | 2 | 7 | 6 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.18 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 67 | 9 | 6 | 2 | 1 | 5.58 | .331 | 1.49 | 11.3 | 2.3 | 9.0 | 40.1 | 50 | 26 | 25 | 5 | 10 | 40 | 0 | 2 | 0 | 0 | 1 | 0 | 2 | 3.38 |