| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 16 | 16 | 9 | 6 | 4.10 | .319 | 1.37 | 8.5 | 3.9 | 10.0 | 109.2 | 103 | 50 | 50 | 13 | 47 | 121 | 0 | 0 | 0 | 0 | 9 | 4 | 2 | 3.73 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 76 | 16 | 16 | 6 | 5 | 3.87 | .295 | 1.22 | 7.0 | 4.0 | 8.6 | 107.0 | 83 | 47 | 46 | 8 | 48 | 102 | 3 | 0 | 0 | 1 | 9 | 3 | 1 | 3.50 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 51 | 15 | 15 | 6 | 5 | 4.42 | .310 | 1.32 | 9.1 | 2.8 | 6.9 | 89.2 | 90 | 48 | 44 | 10 | 28 | 68 | 0 | 0 | 0 | 0 | 9 | 3 | 5 | 3.98 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 41 | 0 | 3 | 4 | 3.33 | .322 | 1.39 | 9.5 | 3.0 | 11.0 | 54.0 | 57 | 28 | 20 | 8 | 18 | 66 | 0 | 6 | 4 | 0 | 0 | 2 | 0 | 3.59 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 34 | 0 | 4 | 3 | 3.64 | .252 | 0.98 | 6.8 | 2.0 | 7.0 | 54.1 | 41 | 25 | 22 | 12 | 12 | 42 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 5.11 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 27 | 0 | 1 | 1 | 2.93 | .320 | 1.41 | 10.7 | 2.3 | 4.3 | 27.2 | 32 | 12 | 9 | 4 | 7 | 13 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 4.74 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 39 | 18 | 0 | 2 | 3 | 5.82 | .330 | 1.43 | 8.6 | 4.7 | 11.1 | 21.2 | 20 | 14 | 14 | 2 | 11 | 26 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.48 |
| RP | Stewart, S.Stewart, Scott >> | 27 | 2002 | L | 28 | 21 | 0 | 2 | 0 | 5.47 | .357 | 1.66 | 12.8 | 2.6 | 9.8 | 24.2 | 34 | 15 | 15 | 2 | 7 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.79 |
| SP | Mulder, M.Mulder, Mark >> | 24 | 2001 | L | 29 | 11 | 0 | 1 | 0 | 3.63 | .342 | 1.50 | 9.5 | 4.2 | 5.3 | 17.1 | 18 | 7 | 7 | 1 | 8 | 10 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.18 |