| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 100 | 15 | 15 | 6 | 3 | 4.05 | .302 | 1.24 | 8.9 | 2.4 | 9.5 | 95.2 | 94 | 48 | 43 | 20 | 25 | 100 | 0 | 0 | 0 | 0 | 8 | 5 | 2 | 4.58 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 15 | 15 | 0 | 3 | 5.34 | .327 | 1.46 | 10.1 | 3.1 | 6.6 | 59.0 | 66 | 36 | 35 | 9 | 20 | 43 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.54 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 15 | 15 | 2 | 8 | 6.19 | .353 | 1.58 | 11.6 | 2.8 | 6.8 | 91.2 | 117 | 68 | 63 | 22 | 28 | 69 | 2 | 0 | 0 | 0 | 7 | 5 | 2 | 5.71 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 15 | 15 | 1 | 11 | 8.32 | .390 | 1.89 | 13.0 | 4.1 | 7.3 | 74.2 | 107 | 69 | 69 | 19 | 34 | 60 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 6.18 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 50 | 14 | 14 | 3 | 9 | 6.61 | .352 | 1.60 | 12.0 | 2.6 | 7.0 | 81.2 | 108 | 61 | 60 | 14 | 23 | 63 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 4.62 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 39 | 0 | 2 | 3 | 5.08 | .320 | 1.41 | 9.3 | 3.5 | 9.5 | 56.2 | 58 | 35 | 32 | 9 | 22 | 59 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 4.16 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 30 | 0 | 4 | 2 | 6.34 | .385 | 1.85 | 13.0 | 3.8 | 9.5 | 38.1 | 55 | 27 | 27 | 9 | 16 | 40 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 5.32 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 30 | 2002 | R | 39 | 33 | 0 | 0 | 2 | 4.60 | .365 | 1.69 | 11.0 | 4.4 | 5.2 | 31.1 | 38 | 16 | 16 | 6 | 15 | 18 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 5.90 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 46 | 1 | 1 | 0 | 1 | 19.64 | .476 | 2.45 | 27.0 | 0.0 | 3.0 | 3.2 | 9 | 8 | 8 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 12.00 |