| SP | Johnson, R.Johnson, Randy † # >> | 38 | 2001 | L | 97 | 25 | 25 | 13 | 8 | 3.74 | .291 | 1.21 | 7.4 | 3.6 | 11.0 | 185.1 | 152 | 80 | 77 | 26 | 73 | 227 | 6 | 0 | 0 | 0 | 15 | 3 | 5 | 3.61 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 24 | 24 | 5 | 7 | 5.90 | .342 | 1.50 | 10.0 | 3.5 | 6.3 | 146.1 | 163 | 100 | 96 | 25 | 56 | 103 | 1 | 0 | 0 | 0 | 9 | 9 | 1 | 5.15 |
| SP | Clement, M.Clement, Matt # >> | 28 | 2002 | R | 53 | 24 | 24 | 5 | 10 | 5.28 | .326 | 1.44 | 8.4 | 4.6 | 9.9 | 151.2 | 141 | 92 | 89 | 18 | 77 | 166 | 0 | 0 | 0 | 0 | 10 | 2 | 3 | 3.92 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 67 | 0 | 3 | 2 | 3.89 | .283 | 1.14 | 8.3 | 2.0 | 10.0 | 104.0 | 96 | 47 | 45 | 8 | 23 | 116 | 0 | 6 | 3 | 0 | 0 | 4 | 0 | 2.55 |
| RP | Broxton, J.Broxton, Jonathan † >> | 25 | 2009 | R | 80 | 65 | 0 | 8 | 4 | 2.84 | .283 | 1.17 | 6.5 | 4.0 | 11.1 | 76.0 | 55 | 24 | 24 | 5 | 34 | 94 | 0 | 13 | 3 | 0 | 0 | 1 | 5 | 2.76 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 60 | 44 | 0 | 4 | 3 | 4.47 | .298 | 1.25 | 6.8 | 4.5 | 10.2 | 46.1 | 35 | 23 | 23 | 5 | 23 | 52 | 0 | 7 | 2 | 0 | 0 | 1 | 1 | 3.72 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 35 | 24 | 0 | 0 | 2 | 4.85 | .315 | 1.38 | 8.7 | 4.0 | 6.8 | 29.2 | 28 | 16 | 16 | 6 | 13 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 5.52 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 47 | 1 | 1 | 0 | 1 | 3.52 | .233 | 0.91 | 9.0 | 0.0 | 7.7 | 7.2 | 7 | 3 | 3 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1.29 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 36 | 13 | 0 | 0 | 2 | 6.62 | .329 | 1.42 | 7.4 | 5.8 | 8.5 | 17.2 | 14 | 14 | 13 | 2 | 11 | 16 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 4.76 |