| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 16 | 16 | 6 | 5 | 4.34 | .291 | 1.20 | 7.7 | 3.1 | 8.2 | 87.0 | 74 | 43 | 42 | 20 | 30 | 79 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 5.31 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 16 | 16 | 8 | 5 | 4.53 | .323 | 1.39 | 9.2 | 3.4 | 10.1 | 91.1 | 93 | 46 | 46 | 16 | 34 | 102 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 4.30 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 86 | 16 | 16 | 5 | 4 | 3.54 | .309 | 1.30 | 10.0 | 1.8 | 6.9 | 104.1 | 115 | 42 | 41 | 15 | 21 | 80 | 1 | 0 | 0 | 0 | 10 | 4 | 2 | 4.06 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 15 | 15 | 9 | 3 | 4.33 | .298 | 1.25 | 9.3 | 2.0 | 6.7 | 87.1 | 90 | 44 | 42 | 11 | 19 | 65 | 0 | 0 | 0 | 0 | 10 | 2 | 3 | 3.87 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 31 | 0 | 3 | 1 | 4.78 | .309 | 1.31 | 10.1 | 1.7 | 9.3 | 32.0 | 36 | 18 | 17 | 1 | 6 | 33 | 0 | 16 | 4 | 0 | 0 | 1 | 0 | 2.00 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 29 | 0 | 1 | 1 | 3.06 | .281 | 1.08 | 6.5 | 3.4 | 7.6 | 32.1 | 23 | 14 | 11 | 1 | 12 | 27 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.13 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 43 | 0 | 4 | 2 | 3.21 | .289 | 1.20 | 6.9 | 4.0 | 10.1 | 47.2 | 36 | 17 | 17 | 5 | 21 | 53 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.53 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 22 | 0 | 1 | 1 | 2.43 | .310 | 1.35 | 7.1 | 5.3 | 4.7 | 29.2 | 23 | 8 | 8 | 3 | 17 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.07 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 56 | 17 | 0 | 1 | 1 | 6.00 | .341 | 1.56 | 6.0 | 8.0 | 7.0 | 18.0 | 12 | 12 | 12 | 2 | 16 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.56 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 24 | 0 | 0 | 0 | 4.07 | .291 | 1.23 | 7.9 | 3.4 | 10.5 | 24.1 | 21 | 12 | 11 | 4 | 9 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.96 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 61 | 13 | 0 | 3 | 1 | 4.37 | .329 | 1.46 | 10.4 | 2.8 | 6.5 | 57.2 | 66 | 33 | 28 | 7 | 18 | 41 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.16 |