| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 25 | 25 | 11 | 7 | 4.57 | .293 | 1.23 | 8.6 | 2.5 | 8.8 | 149.2 | 142 | 76 | 76 | 21 | 42 | 146 | 3 | 0 | 0 | 1 | 11 | 2 | 4 | 3.76 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 25 | 25 | 9 | 8 | 5.64 | .352 | 1.61 | 11.0 | 3.5 | 6.6 | 126.0 | 154 | 91 | 79 | 19 | 49 | 93 | 0 | 0 | 0 | 0 | 10 | 2 | 5 | 4.70 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 24 | 24 | 7 | 6 | 4.52 | .301 | 1.27 | 8.2 | 3.2 | 6.5 | 141.1 | 129 | 76 | 71 | 22 | 50 | 102 | 1 | 0 | 0 | 1 | 13 | 4 | 3 | 4.73 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 23 | 23 | 8 | 7 | 4.27 | .293 | 1.21 | 9.0 | 1.9 | 7.7 | 135.0 | 135 | 65 | 64 | 18 | 28 | 115 | 0 | 0 | 0 | 0 | 13 | 5 | 4 | 3.76 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 48 | 0 | 2 | 2 | 2.22 | .267 | 1.06 | 7.1 | 2.6 | 9.8 | 56.2 | 44 | 14 | 14 | 6 | 16 | 61 | 0 | 6 | 5 | 0 | 0 | 2 | 3 | 3.18 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 63 | 0 | 5 | 3 | 3.65 | .295 | 1.23 | 9.1 | 2.0 | 10.0 | 81.1 | 82 | 37 | 33 | 14 | 18 | 90 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 3.77 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 52 | 0 | 3 | 3 | 5.30 | .329 | 1.45 | 11.2 | 2.0 | 11.2 | 54.1 | 67 | 33 | 32 | 12 | 12 | 67 | 0 | 1 | 2 | 0 | 0 | 1 | 5 | 4.13 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 33 | 0 | 3 | 0 | 3.86 | .295 | 1.23 | 8.7 | 2.3 | 6.4 | 35.0 | 34 | 16 | 15 | 4 | 9 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.91 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 59 | 6 | 1 | 1 | 0 | 9.00 | .393 | 1.94 | 13.2 | 4.2 | 8.5 | 17.0 | 25 | 17 | 17 | 4 | 8 | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5.59 |