| SP | Pettitte, A.Pettitte, Andy >> | 41 | 2012 | L | 84 | 42 | 42 | 17 | 13 | 3.89 | .301 | 1.26 | 8.5 | 2.9 | 7.2 | 270.2 | 255 | 136 | 117 | 25 | 87 | 217 | 2 | 0 | 0 | 2 | 23 | 8 | 3 | 3.65 |
| SP | Sabathia, C.Sabathia, CC >> | 33 | 2012 | L | 86 | 42 | 42 | 20 | 13 | 3.40 | .299 | 1.25 | 8.4 | 2.8 | 7.7 | 307.0 | 287 | 125 | 116 | 32 | 97 | 263 | 7 | 0 | 0 | 2 | 26 | 8 | 6 | 3.67 |
| SP | Kuroda, H.Kuroda, Hiroki >> | 38 | 2012 | R | 78 | 40 | 40 | 8 | 16 | 5.16 | .344 | 1.56 | 10.6 | 3.5 | 6.7 | 252.2 | 297 | 165 | 145 | 34 | 98 | 188 | 2 | 0 | 0 | 0 | 19 | 2 | 15 | 4.45 |
| SP | Hughes, P.Hughes, Phil >> | 27 | 2012 | R | 67 | 40 | 40 | 19 | 17 | 4.45 | .302 | 1.28 | 9.2 | 2.4 | 7.0 | 244.2 | 249 | 127 | 121 | 31 | 65 | 191 | 1 | 0 | 0 | 0 | 21 | 3 | 4 | 3.92 |
| RP | Rapada, C.Rapada, Clay >> | 32 | 2012 | L | 64 | 81 | 0 | 10 | 2 | 3.70 | .321 | 1.38 | 8.7 | 3.7 | 11.3 | 92.1 | 89 | 44 | 38 | 10 | 38 | 115 | 0 | 6 | 7 | 0 | 0 | 4 | 2 | 3.28 |
| RP | Soriano, R.Soriano, Rafael >> | 34 | 2012 | R | 70 | 74 | 0 | 0 | 5 | 3.22 | .292 | 1.20 | 7.4 | 3.5 | 8.9 | 86.2 | 71 | 34 | 31 | 12 | 33 | 85 | 0 | 12 | 2 | 0 | 0 | 3 | 2 | 4.09 |
| RP | Robertson, D.Robertson, David >> | 28 | 2012 | R | 85 | 56 | 0 | 4 | 2 | 1.73 | .243 | 0.93 | 5.7 | 2.8 | 11.3 | 62.1 | 39 | 12 | 12 | 2 | 19 | 78 | 0 | 8 | 1 | 0 | 0 | 2 | 1 | 1.92 |
| RP | Phelps, D.Phelps, David >> | 26 | 2012 | R | 72 | 33 | 0 | 3 | 8 | 3.26 | .281 | 1.15 | 6.5 | 3.8 | 6.3 | 47.0 | 34 | 18 | 17 | 6 | 20 | 33 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.60 |
| RP | Eppley, C.Eppley, Cody # >> | 27 | 2012 | R | 25 | 34 | 0 | 1 | 0 | 5.12 | .333 | 1.47 | 9.5 | 4.0 | 7.6 | 38.2 | 40 | 24 | 22 | 4 | 17 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.11 |
| RP | Rivera, M.Rivera, Mariano >> | 42 | 2011 | R | 91 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Garcia, F.Garcia, Freddy >> | 37 | 2012 | R | 36 | 18 | 0 | 2 | 3 | 4.74 | .316 | 1.39 | 10.3 | 2.3 | 8.1 | 62.2 | 71 | 39 | 33 | 12 | 16 | 56 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 4.48 |
| SP | Burnett, A.Burnett, A.J. >> | 34 | 2011 | R | 41 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |