| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 30 | 30 | 15 | 9 | 3.63 | .277 | 1.12 | 7.5 | 2.6 | 10.0 | 196.0 | 163 | 85 | 79 | 20 | 57 | 217 | 0 | 0 | 0 | 0 | 21 | 5 | 0 | 3.06 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 85 | 30 | 30 | 5 | 11 | 5.99 | .334 | 1.49 | 9.8 | 3.7 | 5.2 | 157.2 | 171 | 109 | 105 | 25 | 64 | 90 | 0 | 0 | 0 | 0 | 10 | 2 | 2 | 5.18 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 29 | 28 | 16 | 9 | 4.60 | .335 | 1.48 | 10.1 | 3.3 | 4.9 | 215.1 | 241 | 119 | 110 | 23 | 78 | 116 | 11 | 0 | 0 | 1 | 13 | 7 | 3 | 4.50 |
| RP | Betances, D.Betances, Dellin † >> | 26 | 2014 | R | 94 | 80 | 0 | 8 | 3 | 2.76 | .267 | 1.09 | 6.4 | 3.5 | 9.5 | 120.2 | 85 | 40 | 37 | 6 | 47 | 126 | 0 | 10 | 4 | 0 | 0 | 0 | 3 | 2.73 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 70 | 0 | 6 | 8 | 4.00 | .320 | 1.39 | 8.4 | 4.1 | 9.6 | 90.0 | 84 | 42 | 40 | 6 | 41 | 96 | 0 | 7 | 7 | 0 | 0 | 2 | 4 | 3.17 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 58 | 0 | 6 | 3 | 4.09 | .313 | 1.36 | 7.0 | 5.3 | 9.5 | 66.0 | 51 | 30 | 30 | 6 | 39 | 70 | 0 | 11 | 2 | 0 | 0 | 0 | 4 | 3.83 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 38 | 0 | 4 | 2 | 4.84 | .354 | 1.58 | 9.0 | 5.4 | 4.4 | 35.1 | 35 | 22 | 19 | 2 | 21 | 17 | 0 | 3 | 0 | 0 | 0 | 2 | 2 | 4.74 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 23 | 0 | 0 | 0 | 1.69 | .322 | 1.43 | 9.7 | 3.5 | 9.0 | 26.2 | 28 | 7 | 5 | 3 | 10 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.65 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 4 | 0 | 1 | 1 | 8.64 | .405 | 2.04 | 9.0 | 10.1 | 3.4 | 8.1 | 8 | 8 | 8 | 3 | 9 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.50 |