| SP | Kershaw, C.Kershaw, Clayton † # >> | 28 | 2016 | L | 99 | 30 | 30 | 16 | 11 | 3.31 | .251 | 0.99 | 7.7 | 1.3 | 8.2 | 234.0 | 199 | 100 | 86 | 20 | 33 | 212 | 13 | 0 | 0 | 5 | 17 | 3 | 4 | 2.76 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 30 | 30 | 12 | 12 | 4.52 | .305 | 1.29 | 8.7 | 2.9 | 7.9 | 211.0 | 204 | 112 | 106 | 26 | 69 | 186 | 6 | 0 | 0 | 4 | 15 | 5 | 4 | 3.89 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 29 | 29 | 8 | 12 | 4.64 | .318 | 1.38 | 7.9 | 4.6 | 8.0 | 178.1 | 156 | 97 | 92 | 21 | 90 | 159 | 2 | 0 | 0 | 0 | 13 | 4 | 4 | 4.33 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 29 | 29 | 9 | 17 | 5.30 | .331 | 1.44 | 9.6 | 3.4 | 4.7 | 219.0 | 233 | 140 | 129 | 33 | 83 | 114 | 9 | 0 | 0 | 1 | 8 | 9 | 2 | 5.18 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 70 | 0 | 4 | 5 | 3.97 | .308 | 1.30 | 7.4 | 4.4 | 9.8 | 88.1 | 72 | 41 | 39 | 7 | 43 | 96 | 0 | 8 | 4 | 0 | 0 | 3 | 2 | 3.42 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 44 | 0 | 2 | 2 | 4.08 | .322 | 1.40 | 9.6 | 3.1 | 9.0 | 46.1 | 49 | 22 | 21 | 4 | 16 | 46 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.24 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 28 | 0 | 1 | 4 | 5.33 | .352 | 1.59 | 8.7 | 5.7 | 5.3 | 27.0 | 26 | 16 | 16 | 0 | 17 | 16 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 3.81 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 23 | 0 | 3 | 1 | 3.23 | .304 | 1.28 | 7.6 | 3.9 | 3.5 | 39.0 | 33 | 14 | 14 | 5 | 17 | 15 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.28 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 3 | 0 | 1 | 0 | 5.40 | .412 | 2.10 | 15.0 | 6.0 | 6.0 | 3.1 | 5 | 2 | 2 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.67 |