| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 31 | 31 | 11 | 16 | 4.19 | .307 | 1.30 | 8.9 | 2.8 | 8.0 | 225.2 | 222 | 114 | 105 | 26 | 71 | 201 | 8 | 0 | 0 | 2 | 18 | 7 | 2 | 3.76 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 30 | 30 | 7 | 19 | 6.70 | .347 | 1.58 | 11.0 | 3.2 | 8.7 | 184.0 | 224 | 139 | 137 | 32 | 66 | 178 | 2 | 0 | 0 | 1 | 9 | 3 | 8 | 4.45 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 29 | 29 | 11 | 15 | 4.70 | .314 | 1.37 | 9.5 | 2.9 | 5.0 | 214.1 | 225 | 118 | 112 | 28 | 68 | 120 | 10 | 0 | 0 | 1 | 13 | 2 | 5 | 4.56 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 79 | 0 | 4 | 3 | 2.87 | .289 | 1.20 | 8.0 | 2.8 | 10.2 | 103.1 | 92 | 33 | 33 | 7 | 32 | 117 | 0 | 6 | 2 | 0 | 0 | 2 | 1 | 2.60 |
| RP | Miller, A.Miller, Andrew † >> | 29 | 2014 | L | 88 | 51 | 0 | 6 | 3 | 2.30 | .257 | 1.04 | 5.8 | 3.6 | 8.7 | 62.2 | 40 | 16 | 16 | 4 | 25 | 60 | 0 | 7 | 0 | 0 | 0 | 0 | 3 | 3.11 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 33 | 0 | 1 | 1 | 3.92 | .312 | 1.36 | 7.8 | 4.4 | 9.5 | 39.0 | 34 | 18 | 17 | 2 | 19 | 41 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.03 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 32 | 0 | 0 | 0 | 2.37 | .288 | 1.18 | 6.2 | 4.5 | 9.0 | 38.0 | 26 | 12 | 10 | 2 | 19 | 38 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.26 |