| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 13 | 13 | 2 | 8 | 8.57 | .399 | 1.98 | 12.9 | 5.0 | 8.7 | 69.1 | 99 | 67 | 66 | 16 | 38 | 67 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 5.77 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 13 | 13 | 5 | 7 | 4.92 | .320 | 1.41 | 9.1 | 3.7 | 6.6 | 93.1 | 94 | 59 | 51 | 13 | 38 | 68 | 5 | 0 | 0 | 0 | 6 | 0 | 1 | 4.58 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 13 | 13 | 5 | 5 | 5.32 | .351 | 1.60 | 10.9 | 3.5 | 5.9 | 88.0 | 107 | 55 | 52 | 10 | 34 | 58 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 4.39 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 82 | 22 | 0 | 4 | 4 | 2.96 | .261 | 1.06 | 7.0 | 2.7 | 9.7 | 27.1 | 21 | 9 | 9 | 3 | 8 | 29 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.19 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 13 | 0 | 1 | 1 | 3.60 | .297 | 1.20 | 4.8 | 6.0 | 6.0 | 15.0 | 8 | 6 | 6 | 1 | 10 | 10 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 4.73 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 12 | 0 | 0 | 0 | 0.82 | .233 | 0.91 | 8.2 | 0.0 | 9.8 | 11.0 | 10 | 2 | 1 | 0 | 0 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0.82 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 68 | 15 | 0 | 0 | 0 | 1.80 | .338 | 1.53 | 5.4 | 8.4 | 7.8 | 15.0 | 9 | 4 | 3 | 1 | 14 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.93 |