| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 28 | 28 | 11 | 7 | 3.47 | .266 | 1.06 | 7.0 | 2.5 | 8.5 | 197.1 | 154 | 77 | 76 | 30 | 55 | 187 | 1 | 0 | 0 | 1 | 22 | 6 | 6 | 4.01 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 27 | 27 | 11 | 7 | 4.10 | .334 | 1.47 | 9.2 | 4.0 | 10.0 | 149.1 | 153 | 73 | 68 | 24 | 66 | 166 | 0 | 0 | 0 | 0 | 14 | 6 | 6 | 4.32 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 72 | 27 | 27 | 10 | 8 | 4.98 | .327 | 1.44 | 9.3 | 3.6 | 6.6 | 159.0 | 165 | 99 | 88 | 24 | 64 | 117 | 4 | 0 | 0 | 0 | 13 | 3 | 5 | 4.75 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 27 | 26 | 5 | 10 | 6.54 | .361 | 1.65 | 11.4 | 3.5 | 9.0 | 139.0 | 176 | 107 | 101 | 38 | 54 | 139 | 0 | 0 | 0 | 0 | 7 | 6 | 5 | 5.85 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 72 | 0 | 8 | 2 | 2.44 | .274 | 1.12 | 6.4 | 3.8 | 11.0 | 99.2 | 70 | 27 | 27 | 10 | 42 | 121 | 0 | 11 | 2 | 0 | 0 | 1 | 8 | 3.17 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 85 | 70 | 0 | 2 | 5 | 2.85 | .278 | 1.14 | 7.1 | 3.3 | 9.8 | 88.1 | 69 | 30 | 28 | 11 | 32 | 96 | 0 | 11 | 5 | 0 | 0 | 1 | 4 | 3.57 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 50 | 0 | 4 | 3 | 5.32 | .311 | 1.32 | 8.7 | 3.2 | 9.3 | 64.1 | 62 | 39 | 38 | 16 | 23 | 66 | 0 | 2 | 3 | 0 | 0 | 2 | 1 | 5.36 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 64 | 31 | 0 | 3 | 2 | 4.00 | .325 | 1.44 | 7.0 | 6.0 | 6.8 | 36.0 | 28 | 16 | 16 | 6 | 24 | 27 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.67 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 25 | 0 | 0 | 2 | 1.98 | .311 | 1.32 | 7.3 | 4.7 | 8.7 | 27.1 | 22 | 6 | 6 | 1 | 14 | 26 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.22 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 56 | 22 | 0 | 2 | 0 | 3.81 | .291 | 1.23 | 6.2 | 4.8 | 6.2 | 26.0 | 18 | 11 | 11 | 2 | 14 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4.23 |