| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 97 | 18 | 18 | 5 | 5 | 5.52 | .335 | 1.47 | 11.1 | 2.2 | 6.9 | 109.1 | 134 | 69 | 67 | 14 | 27 | 83 | 1 | 0 | 0 | 0 | 9 | 4 | 6 | 4.00 |
| SP | Santana, E.Santana, Ervin >> | 23 | 2006 | R | 82 | 17 | 17 | 8 | 5 | 5.69 | .341 | 1.52 | 10.3 | 3.5 | 6.5 | 99.2 | 113 | 64 | 63 | 12 | 38 | 71 | 0 | 0 | 0 | 0 | 8 | 4 | 4 | 4.41 |
| SP | Colon, B.Colon, Bartolo # >> | 33 | 2005 | R | 80 | 17 | 17 | 6 | 7 | 6.55 | .359 | 1.66 | 11.9 | 3.2 | 5.8 | 101.2 | 133 | 74 | 74 | 17 | 36 | 65 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 5.03 |
| SP | Lackey, J.Lackey, John # >> | 28 | 2006 | R | 78 | 17 | 17 | 4 | 5 | 4.95 | .323 | 1.40 | 8.8 | 3.8 | 7.8 | 109.0 | 107 | 61 | 60 | 11 | 46 | 95 | 0 | 0 | 0 | 0 | 9 | 3 | 11 | 3.92 |
| RP | Escobar, K.Escobar, Kelvim >> | 30 | 2005 | R | 93 | 56 | 0 | 4 | 0 | 2.74 | .289 | 1.15 | 6.6 | 3.8 | 8.4 | 72.1 | 53 | 23 | 22 | 1 | 30 | 67 | 0 | 5 | 0 | 0 | 0 | 5 | 4 | 2.78 |
| RP | Shields, S.Shields, Scot >> | 31 | 2005 | R | 91 | 36 | 0 | 3 | 2 | 4.08 | .338 | 1.47 | 9.3 | 4.1 | 7.7 | 35.1 | 36 | 16 | 16 | 3 | 16 | 30 | 0 | 1 | 2 | 0 | 0 | 2 | 11 | 3.94 |
| RP | Peralta, J.Peralta, Joel >> | 30 | 2005 | R | 84 | 22 | 0 | 0 | 1 | 7.08 | .344 | 1.57 | 12.2 | 2.3 | 4.1 | 20.1 | 27 | 17 | 16 | 2 | 5 | 9 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 4.15 |
| RP | Donnelly, B.Donnelly, Brendan >> | 35 | 2005 | R | 60 | 16 | 0 | 1 | 2 | 3.77 | .348 | 1.53 | 10.3 | 3.9 | 5.1 | 14.1 | 16 | 6 | 6 | 1 | 6 | 8 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.29 |
| CL | Rodriguez, F.Rodriguez, Francisco >> | 24 | 2005 | R | 95 | 33 | 0 | 4 | 4 | 2.89 | .291 | 1.18 | 6.6 | 4.1 | 7.5 | 37.1 | 27 | 12 | 12 | 2 | 17 | 31 | 0 | 17 | 1 | 0 | 0 | 2 | 2 | 3.57 |
| SP | Washburn, J.Washburn, Jarrod >> | 32 | 2005 | L | 55 | 12 | 0 | 3 | 0 | 4.60 | .322 | 1.40 | 9.4 | 3.2 | 4.8 | 45.0 | 47 | 23 | 23 | 6 | 16 | 24 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 4.80 |