| SP | Carpenter, C.Carpenter, Chris # >> | 31 | 2005 | R | 96 | 18 | 18 | 4 | 9 | 4.92 | .322 | 1.39 | 9.6 | 2.9 | 7.8 | 126.1 | 135 | 70 | 69 | 17 | 40 | 109 | 3 | 0 | 0 | 0 | 8 | 5 | 2 | 4.10 |
| SP | Marquis, J.Marquis, Jason >> | 28 | 2005 | R | 64 | 18 | 18 | 5 | 8 | 5.83 | .344 | 1.55 | 11.0 | 3.0 | 4.6 | 75.2 | 92 | 50 | 49 | 11 | 25 | 38 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 4.97 |
| SP | Reyes, A.Reyes, Anthony >> | 25 | 2006 | R | 59 | 17 | 17 | 2 | 6 | 5.01 | .314 | 1.35 | 9.4 | 2.8 | 5.6 | 64.2 | 67 | 38 | 36 | 8 | 20 | 40 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 4.41 |
| SP | Morris, M.Morris, Matt >> | 32 | 2005 | R | 56 | 19 | 17 | 7 | 6 | 4.30 | .318 | 1.37 | 11.2 | 1.3 | 6.8 | 83.2 | 103 | 40 | 40 | 14 | 12 | 63 | 0 | 0 | 1 | 0 | 5 | 2 | 2 | 4.18 |
| SP | Suppan, J.Suppan, Jeff >> | 31 | 2005 | R | 47 | 18 | 16 | 2 | 8 | 6.14 | .346 | 1.56 | 10.4 | 3.6 | 6.1 | 63.0 | 73 | 47 | 43 | 12 | 25 | 43 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 5.40 |
| RP | Wainwright, A.Wainwright, Adam >> | 25 | 2006 | R | 82 | 57 | 0 | 0 | 3 | 4.29 | .314 | 1.33 | 8.2 | 3.8 | 6.0 | 71.1 | 65 | 35 | 34 | 4 | 30 | 47 | 0 | 6 | 3 | 0 | 0 | 3 | 1 | 3.80 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 34 | 2005 | R | 80 | 45 | 0 | 6 | 2 | 3.18 | .298 | 1.20 | 6.1 | 4.8 | 6.6 | 56.2 | 38 | 22 | 20 | 2 | 30 | 41 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 3.82 |
| RP | Flores, R.Flores, Randy >> | 31 | 2005 | L | 76 | 60 | 0 | 4 | 0 | 4.56 | .347 | 1.58 | 11.3 | 3.0 | 10.1 | 51.1 | 64 | 31 | 26 | 7 | 17 | 57 | 0 | 0 | 3 | 0 | 0 | 1 | 5 | 3.61 |
| RP | Hancock, J.Hancock, Josh >> | 28 | 2006 | R | 70 | 50 | 0 | 1 | 3 | 4.16 | .333 | 1.44 | 9.9 | 3.2 | 5.8 | 62.2 | 68 | 29 | 29 | 5 | 22 | 40 | 0 | 7 | 4 | 0 | 0 | 4 | 3 | 4.02 |
| RP | Thompson, B.Thompson, Brad >> | 24 | 2005 | R | 71 | 42 | 0 | 4 | 1 | 4.55 | .304 | 1.27 | 8.4 | 3.2 | 5.8 | 57.1 | 53 | 30 | 29 | 6 | 20 | 37 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 4.23 |