| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 87 | 18 | 18 | 3 | 11 | 6.47 | .355 | 1.62 | 11.4 | 3.1 | 5.6 | 103.0 | 131 | 74 | 74 | 18 | 36 | 64 | 1 | 0 | 0 | 0 | 5 | 3 | 5 | 5.17 |
| SP | Wakefield, T.Wakefield, Tim >> | 40 | 2005 | R | 74 | 17 | 17 | 3 | 10 | 5.08 | .335 | 1.46 | 9.9 | 3.4 | 6.1 | 102.2 | 112 | 59 | 58 | 14 | 38 | 69 | 1 | 0 | 0 | 0 | 9 | 5 | 0 | 4.70 |
| SP | Clement, M.Clement, Matt >> | 32 | 2005 | R | 61 | 17 | 17 | 4 | 9 | 4.63 | .328 | 1.45 | 10.1 | 2.9 | 7.1 | 105.0 | 118 | 57 | 54 | 15 | 34 | 83 | 0 | 0 | 0 | 0 | 7 | 2 | 6 | 4.30 |
| SP | Miller, W.Miller, Wade >> | 30 | 2005 | R | 44 | 17 | 17 | 6 | 8 | 6.51 | .339 | 1.51 | 10.3 | 3.4 | 7.6 | 85.2 | 97 | 64 | 62 | 16 | 32 | 72 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 4.99 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 99 | 40 | 0 | 2 | 4 | 2.95 | .242 | 0.93 | 6.5 | 2.1 | 9.9 | 39.2 | 28 | 13 | 13 | 2 | 9 | 43 | 0 | 15 | 1 | 0 | 0 | 1 | 1 | 2.23 |
| SU | Embree, A.Embree, Alan >> | 36 | 2006 | L | 68 | 46 | 0 | 3 | 1 | 3.96 | .318 | 1.40 | 10.1 | 2.5 | 10.6 | 50.0 | 56 | 22 | 22 | 5 | 14 | 59 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.78 |
| RP | Foulke, K.Foulke, Keith >> | 34 | 2006 | R | 61 | 48 | 0 | 0 | 1 | 5.10 | .318 | 1.37 | 9.9 | 2.4 | 6.6 | 60.0 | 66 | 34 | 34 | 7 | 16 | 44 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 3.95 |
| RP | Timlin, M.Timlin, Mike >> | 40 | 2005 | R | 41 | 41 | 0 | 3 | 0 | 5.86 | .361 | 1.63 | 11.1 | 3.6 | 6.9 | 43.0 | 53 | 28 | 28 | 7 | 17 | 33 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 4.98 |