| SP | Zambrano, C.Zambrano, Carlos >> | 25 | 2005 | R | 94 | 18 | 18 | 7 | 8 | 4.15 | .321 | 1.36 | 8.9 | 3.5 | 6.9 | 125.2 | 123 | 61 | 58 | 15 | 48 | 96 | 1 | 0 | 0 | 0 | 9 | 7 | 1 | 4.34 |
| SP | Maddux, G.Maddux, Greg >> | 40 | 2005 | R | 66 | 17 | 17 | 5 | 5 | 3.61 | .338 | 1.48 | 10.7 | 2.7 | 5.6 | 109.2 | 129 | 52 | 44 | 11 | 33 | 68 | 1 | 0 | 0 | 0 | 9 | 6 | 3 | 4.14 |
| SP | Williams, J.Williams, Jerome >> | 25 | 2005 | R | 63 | 17 | 17 | 2 | 8 | 6.41 | .359 | 1.63 | 10.6 | 4.2 | 5.2 | 92.2 | 108 | 72 | 66 | 16 | 43 | 53 | 0 | 0 | 0 | 0 | 5 | 5 | 1 | 5.67 |
| RP | Wuertz, M.Wuertz, Michael >> | 28 | 2005 | R | 83 | 45 | 0 | 5 | 2 | 4.38 | .333 | 1.48 | 9.7 | 3.7 | 10.1 | 51.1 | 55 | 26 | 25 | 6 | 21 | 57 | 0 | 0 | 2 | 0 | 0 | 1 | 7 | 3.59 |
| RP | Borowski, J.Borowski, Joe >> | 35 | 2005 | R | 78 | 33 | 0 | 1 | 1 | 4.26 | .321 | 1.39 | 9.0 | 3.8 | 6.7 | 31.2 | 31 | 17 | 15 | 1 | 13 | 23 | 0 | 1 | 3 | 0 | 0 | 1 | 4 | 3.29 |
| RP | Aardsma, D.Aardsma, David >> | 25 | 2006 | R | 75 | 20 | 0 | 1 | 0 | 2.16 | .333 | 1.50 | 9.6 | 4.5 | 3.9 | 16.2 | 17 | 5 | 4 | 1 | 8 | 7 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.44 |
| RP | Dempster, R.Dempster, Ryan >> | 29 | 2005 | R | 61 | 16 | 0 | 2 | 0 | 6.95 | .394 | 1.91 | 10.2 | 7.0 | 7.8 | 22.0 | 25 | 17 | 17 | 4 | 17 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.09 |
| SP | Marmol, C.Marmol, Carlos >> | 24 | 2006 | R | 42 | 11 | 0 | 2 | 2 | 7.76 | .428 | 2.17 | 11.5 | 8.1 | 5.3 | 29.0 | 37 | 25 | 25 | 5 | 26 | 17 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 6.97 |